术中回收对用于手术预防的抗生素浓度的影响。
Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis.
机构信息
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
Hartford Healthcare Heart and Vascular Institute, Hartford Hospital, Hartford, Connecticut, USA.
出版信息
Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01725-20.
Abstract
Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation. Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.
摘要
术中细胞回收（IOCS）用于输注手术中丢失的自体血。我们通过 IOCS 系统研究了万古霉素、哌拉西林、氨苄西林和头孢唑林的抗生素分布情况。在 IOCS 再输注袋中仅回收了输注于全血的抗生素的 2%±1%，而 97%±17%则存在于废物中。在接受肝移植的两名患者中，氨苄西林的观察结果得到了证实。有必要进行研究以测量 IOCS 对围手术期抗生素浓度的影响。
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