Fu Ruisen, Yang Haisheng
Department of Biomedical Engineering, College of Environment and Life Science, Beijing University of Technology, Beijing 100124, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Oct 25;37(5):930-935. doi: 10.7507/1001-5515.202004010.
Fracture is a common physical injury. Its healing process involves complex biological activities at tissue, cellular and molecular levels and is affected by mechanical and biological factors. Over recent years, numerical simulation methods have been widely used to explore the mechanisms of fracture healing, design fixators and develop novel treatment strategies, etc. This paper mainly recommend the numerical methods used for simulating fracture healing and their latest research progress, which helps people better understand the mechanism of fracture healing, and also provides direction and guidance for the numerical simulation research of fracture healing in the future. First, the fracture healing process and its relationship with mechanical stimulation and biological factors are described. Then, the numerical models used for simulating fracture healing (including mechano-regulatory model, biological regulatory model and mechano-biological regulatory model) and corresponding modeling techniques (mainly including agent-based techniques and fuzzy logic controlling method) were summarized in particular. Finally, the future research directions in numerical simulation of fracture healing were preliminarily prospected.
骨折是一种常见的身体损伤。其愈合过程涉及组织、细胞和分子水平上复杂的生物学活动,并受到机械和生物学因素的影响。近年来,数值模拟方法已被广泛用于探索骨折愈合机制、设计固定器以及开发新的治疗策略等。本文主要介绍用于模拟骨折愈合的数值方法及其最新研究进展,这有助于人们更好地理解骨折愈合机制,也为未来骨折愈合的数值模拟研究提供方向和指导。首先,描述了骨折愈合过程及其与机械刺激和生物学因素的关系。然后,特别总结了用于模拟骨折愈合的数值模型(包括力学调节模型、生物学调节模型和力学 - 生物学调节模型)以及相应的建模技术(主要包括基于智能体的技术和模糊逻辑控制方法)。最后,对骨折愈合数值模拟的未来研究方向进行了初步展望。
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