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[新冠病毒感染患者的嗅觉障碍:机制与临床意义]

[Smell impairment in COVID-19 patients: mechanisms and clinical significance].

作者信息

Kryukov A I, Kazakova A A, Hecht A B

机构信息

Research Clinical Institute of Otorinolaryngology named after. L.I. Sverzhevsky, Moscow, Russia.

Pirogov Russian National Research Medical University, Moscow, Russia.

出版信息

Vestn Otorinolaringol. 2020;85(5):93-97. doi: 10.17116/otorino20208505193.

DOI:10.17116/otorino20208505193
PMID:33140943
Abstract

Numerous studies have shown that loss of smell is a serious symptom that requires careful differential diagnosis. There is convincing evidence that a violation of the sense of smell is not so much a sign of the pathology of the nasal cavity and paranasal sinuses, but it can be a manifestation of neurodegenerative diseases. Some patients with the identified SARS-CoV-2 virus have neurological symptoms. Most of them are not specific - headache, dizziness, fatigue, myalgia. A small percentage of patients with COVID-19 infection have convulsions, impaired consciousness, and the presence of 2019-NCoV RNA was found in the cerebrospinal fluid. Data on the development of new symptoms of the disease, in the form of anosmia and dysgeusia, are presented.

摘要

大量研究表明,嗅觉丧失是一种需要仔细鉴别诊断的严重症状。有令人信服的证据表明,嗅觉障碍与其说是鼻腔和鼻窦病理的标志,不如说是神经退行性疾病的一种表现。一些确诊感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的患者有神经症状。其中大多数症状不具特异性——头痛、头晕、疲劳、肌痛。一小部分新型冠状病毒肺炎(COVID-19)感染患者有抽搐、意识障碍,且在脑脊液中发现了2019新型冠状病毒(2019-NCoV)核糖核酸(RNA)。本文介绍了以嗅觉减退和味觉障碍形式出现的该疾病新症状的发展数据。

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