Fleck U, Schillinger A, Blech W, Nowak W
Klinik und Poliklinik für Chirurgie, Martin-Luther-Universität Halle-Wittenberg.
Z Exp Chir Transplant Kunstliche Organe. 1987;20(4):212-23.
Changes in the functional connection between the small bowel and Langerhans islet cells after extensive small bowel resection were analyzed. The extension of resection chosen were as follow: resection of proximal small bowel (75%), resection of distal small bowel (66%), resection of ileum (45%). 28 days after operation we examined the reaction of endocrine pancreas with the intraperitoneal glucose tolerance and with the isolated perfused pancreas on glucose stimulation. After extensive resection of the proximal small bowel we found a decreased sensitivity of islet cells on glucose stimulation. This reaction was similar to that observed in diabetes mellitus. Glucose tolerance, insulin- and pancreatic glucagon release in rats after ileum resection were almost normal. In this case we found a reduced level of fasting plasma glucose and of the basal insulin. This was accompanied with an increased food intake during the postoperative period.
分析了广泛小肠切除术后小肠与胰岛细胞之间功能连接的变化。所选择的切除范围如下：近端小肠切除（75%）、远端小肠切除（66%）、回肠切除（45%）。术后28天，我们通过腹腔内葡萄糖耐量试验以及对葡萄糖刺激下分离灌注胰腺的检测，来检查内分泌胰腺的反应。近端小肠广泛切除术后，我们发现胰岛细胞对葡萄糖刺激的敏感性降低。这种反应与在糖尿病中观察到的相似。回肠切除术后大鼠的葡萄糖耐量、胰岛素和胰高血糖素释放几乎正常。在这种情况下，我们发现空腹血浆葡萄糖水平和基础胰岛素水平降低。这伴随着术后期间食物摄入量的增加。
