BRCA1-A 和 BRISC：泛素信号传导的多功能分子机器。

Cryo-EM Knowledge Hub, ETH Zürich, Otto-Stern-Weg 3, HPM C51, 8093 Zürich, Switzerland.

Biomolecules. 2020 Oct 31;10(11):1503. doi: 10.3390/biom10111503.

The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair , edits ubiquitin signals on chromatin, and sequesters BRCA1 away from the site of damage, suppressing homologous recombination by limiting resection. BRISC forms a complex with metabolic enzyme SHMT2 and regulates the immune response, mitosis, and hematopoiesis. Almost two decades of research have revealed how BRCA1-A and BRISC use the same core of subunits to perform very distinct biological tasks.

K63 连接特异性去泛素化酶 BRCC36 构成了两个多亚基去泛素化复合物的核心：BRCA1-A 和 BRISC。BRCA1-A 被招募到 DNA 修复中，编辑染色质上的泛素信号，并将 BRCA1 从损伤部位隔离，通过限制切割来抑制同源重组。BRISC 与代谢酶 SHMT2 形成复合物，调节免疫反应、有丝分裂和造血。近二十年的研究揭示了 BRCA1-A 和 BRISC 如何使用相同的亚基核心来执行非常不同的生物学任务。