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心血管疾病与 SARS-CoV-2：宿主免疫反应与病毒直接损伤的作用。

Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury.

机构信息

Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.

Internal Medicine and Vascular Diseases Unit, 00168 Roma, Italy.

出版信息

Int J Mol Sci. 2020 Oct 30;21(21):8141. doi: 10.3390/ijms21218141.

DOI:10.3390/ijms21218141
PMID:33143371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7663579/
Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

摘要

自 2019 年 12 月开始传播的 2019 年新型冠状病毒（2019-nCoV）引发了全球大流行。除了引发严重急性呼吸系统综合征 2（SARS-CoV-2）外，该病毒还可影响其他器官导致各种症状。SARS-CoV-2 与心血管系统的关系密切，表明 SARS-CoV-2 与心脏损伤之间存在流行病学联系。目前有关于 2019-nCoV 可能直接导致心肌损伤的新数据。在这篇综述中，将讨论最重要的现有证据，以阐明 SARS-CoV-2 患者心血管损伤的确切机制，尽管还需要进一步的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f5/7663579/a3b999ab4ab7/ijms-21-08141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f5/7663579/a3b999ab4ab7/ijms-21-08141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f5/7663579/a3b999ab4ab7/ijms-21-08141-g001.jpg

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Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury.

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引用本文的文献

[1]
Direct, indirect, post-infection damages induced by coronavirus in the human body: an overview.

Virusdisease. 2022-12

[2]
Cardiovascular Outcomes in the Acute Phase of COVID-19.

Int J Mol Sci. 2021-4-15

本文引用的文献

[1]
COVID-19 in people with diabetes: understanding the reasons for worse outcomes.

Lancet Diabetes Endocrinol. 2020-7-17

[2]
COVID-19 Presenting as Takotsubo Cardiomyopathy Complicated with Atrial Fibrillation.

Int J Cardiol Heart Vasc. 2020-7-10

[3]
Dexamethasone in Hospitalized Patients with Covid-19.

N Engl J Med. 2021-2-25

[4]
SARS-CoV-2: An immunogenetics call to arms.

Int J Immunogenet. 2020-7-12

[5]
A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients.

Int J Immunogenet. 2020-7-5

[6]
SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management.

Biochem Pharmacol. 2020-6-21

[7]
SARS-CoV-2 infection-induced immune responses: Friends or foes?

Scand J Immunol. 2020-6-17

[8]
Takotsubo Syndrome Associated with COVID-19.

Eur J Case Rep Intern Med. 2020-4-21

[9]
[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020-5-25

[10]
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.

Ann Intern Med. 2020-5-6

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