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在马来西亚老年人纵向研究 (MELoR) 研究中,55 岁及以上的城市居民中跌倒、虚弱和代谢综合征 - 一项横断面研究。

Falls, frailty, and metabolic syndrome in urban dwellers aged 55 years and over in the Malaysian elders longitudinal research (MELoR) study - a cross-sectional Study.

机构信息

Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Postgrad Med. 2021 Apr;133(3):351-356. doi: 10.1080/00325481.2020.1842026. Epub 2020 Nov 3.

Abstract

OBJECTIVES

While metabolic syndrome, falls, and frailty are common health issues among older adults which are likely to be related, the potential interplay between these three conditions has not previously been investigated. We investigated the relationship between metabolic syndrome with falls, and the role of frailty markers in this potential relationship, among community-dwelling older adults.

METHODS

Data from the first wave Malaysian Elders Longitudinal Research (MELoR) study comprising urban dwellers aged 55 years and above were utilized. Twelve-month fall histories were established during home-based, computer-assisted interviews which physical performance, anthropometric and laboratory measures were obtained during a hospital-based health check. Gait speed, exhaustion, weakness, and weight loss were employed as frailty markers.

RESULTS

Data were available for 1415 participants, mean age of 68.56 ± 7.26 years, 57.2% women. Falls and metabolic syndrome were present in 22.8% and 44.2%, respectively. After adjusting for age, sex, and multiple comorbidities, metabolic syndrome was significantly associated with falls in the sample population [odds ratio (OR): 1.33, 95% confidence interval (CI): 1.03; 1.72]. This relationship was attenuated by the presence of slow gait speed, but not exhaustion, weakness, or weight loss.

CONCLUSION

Metabolic syndrome was independently associated with falls among older adults, and this relationship was accounted for by the presence of slow gait speed. Future studies should determine the value of screening for frailty and falls with gait speed in older adults with metabolic syndrome as a potential fall prevention measure.

摘要

目的

代谢综合征、跌倒和衰弱是老年人常见的健康问题,它们可能相互关联,但这三种情况之间的潜在相互作用尚未得到研究。我们调查了社区居住的老年人中代谢综合征与跌倒之间的关系,以及衰弱标志物在这种潜在关系中的作用。

方法

利用了来自马来西亚老年人纵向研究(MELoR)第一波的数据,该研究对象为年龄在 55 岁及以上的城市居民。通过家庭为基础、计算机辅助的访谈确定了 12 个月的跌倒史,并在医院进行健康检查时获得了身体表现、人体测量和实验室测量。步速、疲惫、虚弱和体重减轻被用作衰弱标志物。

结果

本研究共有 1415 名参与者,平均年龄为 68.56 ± 7.26 岁,57.2%为女性。跌倒和代谢综合征的发生率分别为 22.8%和 44.2%。在调整了年龄、性别和多种合并症后,代谢综合征与研究人群中的跌倒显著相关[比值比(OR):1.33,95%置信区间(CI):1.03;1.72]。这种关系在存在缓慢的步速时减弱,但在存在疲惫、虚弱或体重减轻时不会减弱。

结论

代谢综合征与老年人跌倒独立相关,这种关系可归因于步速缓慢。未来的研究应该确定在代谢综合征的老年人中,使用步态速度筛查衰弱和跌倒作为潜在的跌倒预防措施的价值。

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