Gleason grade 5 prostate cancer: sub-patterns and prognosis.

Since the conception of the Gleason grading system, several modifications have been made, including the definition of Gleason pattern 5 (GP5) and its reporting in biopsies and prostatectomy specimens. This includes the addition of a few GP5 sub-patterns over time such as single file, solid cylinders and pseudorosetting. Comedonecrosis was also adopted as a GP5 pattern, but in 2014 the International Society of Urological Pathology (ISUP) excluded intraductal carcinoma with comedonecrosis from the GP5 sub-patterns, although the vast majority of cases with comedonecrosis actually represent intraductal carcinoma. The 2019 conference on prostate cancer grading re-adopted comedonecrosis as GP5, also if found in intraductal carcinoma. It is well-established that presence of GP5 conveys an unfavourable prognosis for the patient with regards to risk of lymph node and distant metastasis as well as death of disease. However, there is a paucity of data on the prognostic impact of individual GP5 sub-patterns. In biopsies the frequency of diagnosis of GP5 is about 1-5% in most published series and the most common GP5 sub-pattern is single files and single cells. In an institutional biopsy review study we noted an increase in GP5 diagnosis over time which could not be attributed to the adoption of new GP5 sub-patterns or to overdiagnosis, but might be associated with changing biopsy indications. Further studies on the prognostic impact of GP5 sub-patterns and their molecular genetic profile are indicated.