Kujur Milli Suchita, Manakari Vyasaraj, Parande Gururaj, Prasadh Somasundaram, Wong Raymond, Mallick Ashis, Gupta Manoj
Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, India; Department of Mechanical Engineering, National University of Singapore, Singapore.
Department of Mechanical Engineering, National University of Singapore, Singapore.
J Mech Behav Biomed Mater. 2021 Feb;114:104162. doi: 10.1016/j.jmbbm.2020.104162. Epub 2020 Oct 27.
Magnesium-Zinc based nanocomposites containing cerium oxide nanoparticles were developed in the present work. A systematic study on their microstructure, mechanical properties, in vitro degradation behaviour, and cytotoxicity are presented. It was found that the developed nanocomposites exhibited excellent strength and toughness that are superior to the commercially available magnesium alloys. From corrosion perspective, nanocomposites exhibited reduced pH increase compared to pure Mg with Mg-0.5Zn/0.5CeO showing the least corrosion rate. Moreover, the developed nanocomposites exhibited no cytotoxicity to MC3T3-E1 pre-osteoblast cells. Based on the above findings, the feasibility of Mg-Zn/CeO nanocomposites for use as orthopaedic implants is systematically discussed. This study provides an insight into the development of new high-performance Mg alloy-rare earth oxide (REO)-based nanocomposites with superior mechanical properties and corrosion resistance while effectively avoiding the possible standing toxic effect of RE elements.
在本研究中制备了含有氧化铈纳米颗粒的镁锌基纳米复合材料。对其微观结构、力学性能、体外降解行为和细胞毒性进行了系统研究。结果发现，所制备的纳米复合材料表现出优异的强度和韧性，优于市售镁合金。从腐蚀角度来看，与纯镁相比，纳米复合材料的pH值升高幅度较小，其中Mg-0.5Zn/0.5CeO的腐蚀速率最低。此外，所制备的纳米复合材料对MC3T3-E1前成骨细胞无细胞毒性。基于上述发现，系统地讨论了Mg-Zn/CeO纳米复合材料用作骨科植入物的可行性。本研究为开发具有优异力学性能和耐腐蚀性的新型高性能镁合金-稀土氧化物（REO）基纳米复合材料提供了思路，同时有效避免了稀土元素可能存在的毒性作用。
