Vitreoretina Services, All India Institute of Medical Sciences, New Delhi, India.
Vitreoretina Services, All India Institute of Medical Sciences, New Delhi, India.
J AAPOS. 2021 Feb;25(1):47-50. doi: 10.1016/j.jaapos.2020.08.007. Epub 2020 Nov 2.
Aggressive posterior retinopathy of prematurity (APROP) is the most severe form of retinopathy of prematurity (ROP), with rapid progression to tractional retinal detachment. Exudative retinal detachment (ERD) has rarely been described as a primary presentation in ROP. We present a case of unlasered zone 1 APROP in a 34-week infant presenting with bilateral ERD, which was treated with intravitreal ranibizumab. After injection, the left eye developed acute endophthalmitis, which was managed by intravitreal antibiotic therapy and early vitrectomy. Subsequent laser photocoagulation of the avascular areas resulted in regression of ROP. This case highlights the role of intravitreal anti-vascular endothelial growth factor in treating ERD in APROP and the need for close observation for endophthalmitis after injection.
早产儿急性后部型视网膜病变（APROP）是最严重的早产儿视网膜病变（ROP）形式，其迅速进展为牵引性视网膜脱离。渗出性视网膜脱离（ERD）在 ROP 中很少作为主要表现描述。我们报告了一例 34 周龄婴儿的未激光治疗的 1 区 APROP，该婴儿表现为双侧 ERD，采用玻璃体内雷珠单抗治疗。注射后，左眼发生急性眼内炎，通过玻璃体内抗生素治疗和早期玻璃体切除术进行治疗。随后对无血管区进行激光光凝，ROP 得到消退。该病例强调了玻璃体内抗血管内皮生长因子在治疗 APROP 中 ERD 的作用，以及注射后需要密切观察眼内炎的发生。
