Yamaguchi S, Narumi Y, Nakano E, Fujioka H, Okuyama A
Department of Urology, School of Medicine, Osaka University.
Hinyokika Kiyo. 1987 Jun;33(6):945-50.
A case of primary carcinoma of the male urethra is reported. A 72-year-old male who complained of dysuria and a perineal mass, was admitted to our hospital in April, 1982. Irregularity and narrowing of bulbous urethra were detected on the urethrocystogram and the biopsied specimen from the perineal mass showed the histological findings of squamous cell carcinoma. Total penectomy, total cystectomy, construction of ileal conduit and pelvic lymphadenectomy were performed. The tumor, 10 X 6 X 5 cm in size, was located in the bulbous urethra and the histological diagnosis was well differentiated squamous cell carcinoma with no lymph node metastasis. In spite of postoperative administration of bleomycin, local recurrence appeared 3 months after operation and the patient died from disease progression in August, 1983. The age, histopathology, symptoms, past history, site of tumor, treatment and prognosis in 126 Japanese cases of primary male urethral tumor including the present case were reviewed. En bloc exenteration including resection of the inferior rami or pubic bone with chemotherapy and radiotherapy is recommended for advanced carcinoma of bulbomenbrous urethra.
报告一例男性原发性尿道癌。一名72岁男性,因排尿困难及会阴肿物就诊,于1982年4月入院。尿道膀胱造影显示球部尿道不规则及狭窄,会阴肿物活检标本显示为鳞状细胞癌的组织学表现。遂行全阴茎切除术、全膀胱切除术、回肠代膀胱术及盆腔淋巴结清扫术。肿瘤大小为10×6×5cm,位于球部尿道,组织学诊断为高分化鳞状细胞癌,无淋巴结转移。尽管术后给予博来霉素治疗,但术后3个月出现局部复发,患者于1983年8月因疾病进展死亡。回顾了包括本例在内的126例日本男性原发性尿道肿瘤患者的年龄、组织病理学、症状、既往史、肿瘤部位、治疗及预后情况。对于球膜部尿道晚期癌,建议行包括切除耻骨下支或耻骨在内的整块脏器切除术,并联合化疗和放疗。