骨膜蛋白在雌性犬乳腺癌细胞中的表达。
Expression of Periostin in Mammary Cancer Cells of Female Dogs.
机构信息
Department of Pathology, Division of Pathomorphology and Forensic Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
Department of Pathology, Division of Pathomorphology and Forensic Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
出版信息
In Vivo. 2020 Nov-Dec;34(6):3255-3262. doi: 10.21873/invivo.12162.
BACKGROUND/AIM: Periostin (POSTN) has a significant role in proliferation and migration of tumour cells as well as tumour progression. This study aimed to determinate POSTN expression in cancer cells in malignant and benign tumours of the mammary gland in female dogs.
MATERIALS AND METHODS
All together 83 cancers, 24 adenomas and 7 unchanged fragments of the mammary glands of bitches were investigated. Immunohistochemistry was performed using anti-POSTN, Ki-67 and HER2 antibodies.
RESULTS
POSTN expression was observed in cancer cells in 31.3% of malignancies and 12.5% of benign tumours. A significantly positive correlation between expression of POSTN in cancer cells and the degree of histological malignancy, expression of Ki-67 antigen and expression of POSTN in CAFs was found.
CONCLUSION
The obtained results suggest the possible participation of POSTN in the process of carcinogenesis and progression of mammary tumors in bitches.
背景/目的：骨膜蛋白（POSTN）在肿瘤细胞的增殖和迁移以及肿瘤进展中具有重要作用。本研究旨在确定雌性犬乳腺良恶性肿瘤中癌细胞中 POSTN 的表达。
材料和方法
共研究了 83 例癌症、24 例腺瘤和 7 例犬乳腺未改变片段。使用抗 POSTN、Ki-67 和 HER2 抗体进行免疫组织化学染色。
结果
在 31.3%的恶性肿瘤和 12.5%的良性肿瘤中观察到癌细胞中 POSTN 的表达。发现癌细胞中 POSTN 的表达与组织学恶性程度、Ki-67 抗原的表达以及 CAFs 中 POSTN 的表达之间呈显著正相关。
结论
研究结果表明，POSTN 可能参与了犬乳腺肿瘤的癌变和进展过程。
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