Wasik Adrian, Ratajczak-Wielgomas Katarzyna, Badzinski Arkadiusz, Dziegiel Piotr, Podhorska-Okolow Marzenna
Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Silesian Nanomicroscopy Center, Silesia LabMed: Research and Implementation Center, Medical University of Silesia, 41-800 Zabrze, Poland.
Cancers (Basel). 2022 Aug 30;14(17):4225. doi: 10.3390/cancers14174225.
Periostin (POSTN) is a protein that is part of the extracellular matrix (ECM) and which significantly affects the control of intracellular signaling pathways (PI3K-AKT, FAK) through binding integrin receptors (αvβ3, αvβ5, α6β4). In addition, increased POSTN expression enhances the expression of VEGF family growth factors and promotes Erk phosphorylation. As a result, this glycoprotein controls the Erk/VEGF pathway. Therefore, it plays a crucial role in the formation of new blood and lymphatic vessels, which may be significant in the process of metastasis. Moreover, POSTN is involved in the proliferation, progression, migration and epithelial-mesenchymal transition (EMT) of tumor cells. Its increased expression has been detected in many cancers, including breast cancer, ovarian cancer, non-small cell lung carcinoma and glioblastoma. Many studies have shown that this protein may be an independent prognostic and predictive factor in many cancers, which may influence the choice of optimal therapy.
骨膜蛋白（POSTN）是一种细胞外基质（ECM）的组成蛋白，它通过结合整合素受体（αvβ3、αvβ5、α6β4）显著影响细胞内信号通路（PI3K-AKT、FAK）的调控。此外，POSTN表达增加会增强VEGF家族生长因子的表达并促进Erk磷酸化。因此，这种糖蛋白控制着Erk/VEGF通路。所以，它在新血管和淋巴管形成中起关键作用，这在转移过程中可能具有重要意义。此外，POSTN参与肿瘤细胞的增殖、进展、迁移和上皮-间质转化（EMT）。在许多癌症中都检测到其表达增加，包括乳腺癌、卵巢癌、非小细胞肺癌和胶质母细胞瘤。许多研究表明，这种蛋白可能是多种癌症的独立预后和预测因子，可能会影响最佳治疗方案的选择。
