Department of Medicine, Guthrie Clinic/Robert Packer Hospital, Sayre, PA, U.S.A.
Washington Hospital Healthcare System, Fremont, CA, U.S.A.
In Vivo. 2020 Nov-Dec;34(6):3597-3600. doi: 10.21873/invivo.12204.
Extranodal marginal zone lymphoma (EMZL) presents only rarely within the breast, although the incidence of breast EMZL has increased in the past decade for unclear reasons. Due to its rarity, the etiology, course, and treatment response of this cancer are less studied. Case Report: We present the case of a 64-year-old female who had bilateral diffuse irregularity in a trabecular pattern on screening mammogram. Random ultrasound-guided breast biopsy of the right breast demonstrated an extra-nodal marginal zone B-cell lymphoma. She also had approximately 25% marrow involvement by mucosa-associated lymphoid tissue-type marginal zone lymphoma and splenomegaly. Clinically she remained asymptomatic during a 1-year follow-up. Although she presented with advanced-stage disease involving both breasts, spleen and bone marrow, given her lack of associated symptoms, she was observed with active surveillance. Conclusion: Asymptomatic cases of breast EMZL can be managed with close observation as exemplified by our case.
结外黏膜相关边缘区 B 细胞淋巴瘤（EMZL）在乳腺中很少见，尽管其发病率在过去十年中不明原因地增加。由于其罕见性，这种癌症的病因、病程和治疗反应的研究较少。病例报告：我们报告了一例 64 岁女性的病例，其在筛查性乳房 X 线摄影中表现为双侧弥漫性小梁状不规则性。右侧乳房的随机超声引导下乳房活检显示结外黏膜相关边缘区 B 细胞淋巴瘤。她还患有约 25%的骨髓黏膜相关淋巴组织型边缘区淋巴瘤和脾肿大。在 1 年的随访中，她无任何临床症状。尽管她患有涉及双侧乳房、脾脏和骨髓的晚期疾病，但由于她没有相关症状，因此她通过主动监测进行观察。结论：无症状的乳腺 EMZL 病例可以通过密切观察来管理，我们的病例就是一个例子。
