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SWI/SNF 复合物的特异性组成在前列腺癌谱系可塑性中的作用。

Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.

机构信息

Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.

The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.

出版信息

Nat Commun. 2020 Nov 3;11(1):5549. doi: 10.1038/s41467-020-19328-1.

DOI:10.1038/s41467-020-19328-1
PMID:33144576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7642293/
Abstract

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10-20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors.

摘要

晚期前列腺癌最初对激素治疗有反应，但最终会产生抗药性，需要更有效的治疗方法。大约 10-20%的患者会出现一种耐药机制，即谱系可塑性，表现为部分或完全的小细胞或神经内分泌前列腺癌（NEPC）表型。在这里，我们研究了哺乳动物 SWI/SNF（mSWI/SNF）染色质重塑复合物在 NEPC 中的作用。我们使用大型患者数据集、患者来源的类器官和癌细胞系，鉴定出在 NEPC 中失调的 mSWI/SNF 亚基，并证明 SMARCA4（BRG1）过表达与侵袭性疾病相关。我们还表明，与前列腺腺癌相比，SWI/SNF 复合物在 NEPC 中与不同谱系特异性因子相互作用。这些数据表明 mSWI/SNF 复合物在治疗相关谱系可塑性中发挥作用，这对于其他实体瘤也可能相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/21349d1c2939/41467_2020_19328_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/610bdfcfdf7d/41467_2020_19328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/2537e63fcc6f/41467_2020_19328_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/cddf39e36a37/41467_2020_19328_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/7150d22d8e1d/41467_2020_19328_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/21349d1c2939/41467_2020_19328_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/610bdfcfdf7d/41467_2020_19328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/2537e63fcc6f/41467_2020_19328_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/cddf39e36a37/41467_2020_19328_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/7150d22d8e1d/41467_2020_19328_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/7642293/21349d1c2939/41467_2020_19328_Fig5_HTML.jpg

相似文献

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Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.

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[6]
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[7]
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[2]
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Pharm Res. 2025-8

[3]
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EMBO Mol Med. 2025-8-4

[4]
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Nat Commun. 2025-8-2

[5]
New Insights into Potential Therapeutic Targets for Neuroendocrine Prostate Cancer: From Bench to Clinic.

Research (Wash D C). 2025-7-31

[6]
Reappraisal of Neuroendocrine Tumor Classification of the Prostate Gland: Translating Molecular Insights into Clinical Practice.

Endocr Pathol. 2025-7-23

[7]
NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling.

Nat Genet. 2025-7-21

[8]
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Nat Cancer. 2025-6-16

[9]
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Cell Death Dis. 2025-4-22

[10]
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J Exp Clin Cancer Res. 2025-4-3

本文引用的文献

[1]
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen.

Sci Rep. 2019-12-13

[2]
Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial.

Lancet Oncol. 2019-11-11

[3]
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer.

J Clin Invest. 2019-7-30

[4]
Patterns of care and outcomes in small cell carcinoma of the prostate: A national cancer database analysis.

Prostate. 2019-9

[5]
The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers.

Sci Rep. 2019-7-4

[6]
Cortical and Commissural Defects Upon HCF-1 Loss in Nkx2.1-Derived Embryonic Neurons and Glia.

Dev Neurobiol. 2019-6-25

[7]
Epidemiology of Prostate Cancer.

World J Oncol. 2019-4

[8]
Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.

Cell Death Differ. 2020-1

[9]
Genomic correlates of clinical outcome in advanced prostate cancer.

Proc Natl Acad Sci U S A. 2019-5-6

[10]
EZH2 Inhibitors: Take It EZy, It Is All About Context.

Cancer Discov. 2019-4

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