Relationship between and mutations in stool for identifying colorectal cancer: A cross-sectional study.

BACKGROUND

With early diagnosis, colorectal cancer (CRC) is a curable disease. As studies in the past 15 years have shown, specific genetic changes occur in the neoplastic transformation of normal colonic epithelium to benign adenoma until becoming adenocarcinoma. Considering that dynamic, we aimed to determine how v-raf murine sarcoma viral oncogene homolog B1 and Kirsten rat sarcoma mutations relate to the location, histopathology, and degree of tumor differentiation in CRC.

METHODS

With a cross-sectional design involving an observational analytical approach, we determined the relationship of and mutations to the location, histopathology, and degree of tumor differentiation in CRC.

RESULT

The sample contained 43 patients with CRC aged 21-80 years, with an average age of 56.0 ± 11.2 years, 46.5% of whom were male and 53.5% female, for a male-to-female ratio of 1.0-1.15. Most tumors were located in the right colon ( = 18, 41.9%), followed by the rectum ( = 14, 32.6%) and left colon ( = 18, 25.6%). Non-mucinous adenocarcinoma was more prevalent than mucinous adenocarcinoma, with 22 (51.2%) and 21 (48.8%) patients, respectively. Nineteen tumors were poorly differentiated (44.2%), 15 were moderately differentiated (34.9%), and nine were well-differentiated (20.9%). mutations totaled six (14%), whereas non- mutations totaled 37 (86.0%). mutations significantly related to tumor location, degree of differentiation, and histopathology ( .01).

CONCLUSION

A significant relationship exists between mutations in the stool of patients with CRC and location, histopathology, and degree of tumor differentiation.