Kocián Petr, Whitley Adam, Blaha Milan, Hoch Jiří
a Department of Surgery, 2nd Faculty of Medicine , Charles University and Motol University Hospital , Prague , Czech Republic.
b 2nd Faculty of Medicine , Charles University , Prague , Czech Republic.
Acta Chir Belg. 2017 Dec;117(6):356-362. doi: 10.1080/00015458.2017.1321270. Epub 2017 May 4.
Colorectal cancer (CRC) in young patients is not an uncommon disease. Reports on its behaviour in young patients are conflicting. The aim of this study was to investigate patient and tumour characteristics, treatment and prognosis of this disease.
Our study group comprised all patients under the age of 40 years treated with CRC at the Department of Surgery at Motol University Hospital in Prague between the years 2005 and 2015.
Thirty-eight patients under 40 years of age diagnosed with CRC were included in the study. Five patients had Lynch syndrome and six had first-degree relatives with CRC. There were 22 rectal tumours. All but four patients underwent resection of the primary tumour, all patients received chemotherapy and 13 patients received biological therapy. Disease recurrence occurred in 25.8%. Five-year survival was 47.9%. Advanced disease and adverse histological subtypes were identified as poor prognostic factors.
Colorectal cancer in young patients has a high incidence of predisposing conditions, aggressive histological features and advanced disease. Young patients are of a good state of health and thus should receive aggressive therapy. Clinicians should pay more attention to symptoms of CRC in young patients to be able to initiate early treatment.
年轻患者的结直肠癌并非罕见疾病。关于其在年轻患者中的表现的报道相互矛盾。本研究的目的是调查该疾病的患者和肿瘤特征、治疗及预后。
我们的研究组包括2005年至2015年间在布拉格莫托尔大学医院外科接受结直肠癌治疗的所有40岁以下患者。
38例40岁以下诊断为结直肠癌的患者被纳入研究。5例患者患有林奇综合征，6例患者有患结直肠癌的一级亲属。有22例直肠肿瘤。除4例患者外，所有患者均接受了原发肿瘤切除术，所有患者均接受了化疗，13例患者接受了生物治疗。疾病复发率为25.8%。五年生存率为47.9%。晚期疾病和不良组织学亚型被确定为不良预后因素。
年轻患者的结直肠癌易患情况发生率高、组织学特征侵袭性强且疾病晚期。年轻患者健康状况良好，因此应接受积极治疗。临床医生应更加关注年轻患者的结直肠癌症状以便能够尽早开始治疗。
