韩国女性肺癌的特征：韩国国家肺癌登记处分析
Characteristics of female lung cancer in Korea: analysis of Korean National Lung Cancer Registry.
作者信息
Lim Jeong Uk, Han Solji, Kim Ho Cheol, Choi Chang Min, Jung Chi Young, Cho Deog Gon, Jeon Jae Hyun, Lee Jeong Eun, Ahn Jin Seok, Kim Yeongdae, Choi Yoo-Duk, Suh Yang-Gun, Kim Jung-Eun, Won Young-Joo, Kim Young-Chul, Park Chan Kwon, Kim Seung Joon
机构信息
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Applied Statistics, Yonsei University, Seoul, Korea.
出版信息
J Thorac Dis. 2020 Sep;12(9):4612-4622. doi: 10.21037/jtd-20-1671.
BACKGROUNDS
The present study evaluated Korean women with lung cancer and compared the clinical characteristics of ever-smoker and never-smoker groups using the National Lung Cancer Registry.
METHODS
In affiliation with the Korean Central Cancer Registry, the Korean Association for Lung Cancer constructed a registry into which 10% of the lung cancer cases in Korea were registered. Female lung cancer patients with valid smoking history were evaluated.
RESULTS
Among 735 female lung cancer patients, 643 (87.5%) were never-smokers and 92 (12.5%) were smokers. The median survival was significantly longer in the never-smoker group (28 14 months; P<0.001). Among 683 patients with non-small cell lung cancer (NSCLC), the never-smoker group showed significantly longer median survival (29 14 months; P=0.002) and a higher proportion of stage I cancer (40.3% 25.7%; P<0.001). Survival analysis of the NSCLC patients showed that smoking status, receiving only supportive care, EGFR mutation status, lung cancer stage, and forced vital capacity (FVC) (%) were significantly associated with mortality in the multivariate analysis (P=0.025, HR 2.39, 95% CI: 1.12-5.11; P=0.017, HR 3.14, 95% CI: 1.22-8.06; P=0.033, HR 0.63, 95% CI: 0.41-0.96; P<0.001, HR 11.88, 95% CI: 5.79-24.38; P=0.002, HR 0.98, 95% CI: 0.96-0.99, respectively).
CONCLUSIONS
In Korean women with NSCLC, smoking status, not receiving active anticancer treatment, EGFR mutation status, lung cancer stage, and pulmonary function were significantly associated with mortality.
背景
本研究对韩国肺癌女性患者进行了评估，并利用国家肺癌登记处比较了曾经吸烟者和从不吸烟者群体的临床特征。
方法
韩国肺癌协会与韩国中央癌症登记处合作，建立了一个登记处，登记了韩国10%的肺癌病例。对有有效吸烟史的女性肺癌患者进行了评估。
结果
在735例女性肺癌患者中，643例（87.5%）为从不吸烟者，92例（12.5%）为吸烟者。从不吸烟者组的中位生存期明显更长（28±14个月；P<0.001）。在683例非小细胞肺癌（NSCLC）患者中，从不吸烟者组的中位生存期明显更长（29±14个月；P=0.002），且I期癌症的比例更高（40.3%对25.7%；P<0.001）。NSCLC患者的生存分析表明，在多变量分析中，吸烟状况、仅接受支持性治疗、表皮生长因子受体（EGFR）突变状态、肺癌分期和用力肺活量（FVC）（%）与死亡率显著相关（P=0.025，风险比[HR]2.39，95%置信区间[CI]：1.12 - 5.11；P=0.017，HR 3.14，95%CI：1.22 - 8.06；P=0.033，HR 0.63，95%CI：0.41 - 0.96；P<0.001，HR 11.88，95%CI：5.79 - 24.38；P=0.002，HR 0.98，95%CI：0.96 - 0.99）。
结论
在韩国NSCLC女性患者中，吸烟状况、未接受积极抗癌治疗、EGFR突变状态、肺癌分期和肺功能与死亡率显著相关。
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