Song Junli, Hou Jie, Zhao Qiang, Liu Xuezhi, Guo Qian, Yin Donghong, Song Yan, Li Xiaoxia, Wang Shuyun, Wang Xinchun, Duan Jinju
Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Department of Pharmacy, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi 030001, China.
Int J Hypertens. 2020 Oct 14;2020:1878917. doi: 10.1155/2020/1878917. eCollection 2020.
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of homocysteine metabolism and is closely related to the occurrence of hypertension. The aim of this study was to investigate the polymorphism of the (MTHFR) C677T and the factors influencing the severity of hypertension. . A total of 985 subjects were enrolled to analyze the polymorphisms of the MTHFR C677T gene by polymerase chain reaction (PCR). 306 people with essential hypertension were selected from 985 subjects to estimate the severity of hypertension by the ordinal multivariate logistical regression model.
The frequencies of CC, CT, and TT genotypes were 19.5%, 49.95%, and 30.46%, respectively. The allelic frequency of mutant was 55.43%. The plasma homocysteine level of the homozygous TT in individuals was significantly higher than in those with CC or CT ( < 0.01). MTHFR677CT genotype, MTHFR677TT genotype, smoking, family history of hypertension, Hcy, and triglycerides (TG) were independent risk factors for the severity of hypertension (OR = 2.29, 2.24, 2.04, 1.81, 1.04, 1.26).
MTHFR gene, smoking, family history of hypertension, Hcy, and triglycerides could be important genetic and high-risk factors of the development of severe hypertension in northern Chinese. These factors will contribute to the identification of high-risk populations of hypertension and facilitate the development of hypertension control strategies.
亚甲基四氢叶酸还原酶（MTHFR）是同型半胱氨酸代谢的关键酶，与高血压的发生密切相关。本研究旨在探讨MTHFR基因C677T多态性及影响高血压严重程度的因素。共纳入985名受试者，采用聚合酶链反应（PCR）分析MTHFR C677T基因多态性。从985名受试者中选取306例原发性高血压患者，采用有序多变量逻辑回归模型评估高血压的严重程度。
CC、CT和TT基因型频率分别为19.5%、49.95%和30.46%。突变等位基因频率为55.43%。纯合子TT个体的血浆同型半胱氨酸水平显著高于CC或CT个体（P<0.01）。MTHFR677CT基因型、MTHFR677TT基因型、吸烟、高血压家族史、同型半胱氨酸（Hcy）和甘油三酯（TG）是高血压严重程度的独立危险因素（OR=2.29、2.24、2.04、1.81、1.04、1.26）。
MTHFR基因、吸烟、高血压家族史、Hcy和甘油三酯可能是中国北方严重高血压发生的重要遗传和高危因素。这些因素将有助于识别高血压高危人群，并促进高血压控制策略的制定。
