Department of Biostatistics and Epidemiology, College of Health Sciences, School of Public health, Aksum University, Axum, Ethiopia.
Department of Clinical Midwifery, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Biomed Res Int. 2020 Oct 21;2020:4743974. doi: 10.1155/2020/4743974. eCollection 2020.
Neonatal jaundice is common a clinical problem worldwide. Globally, every year, about 1.1 million babies develop severe hyperbilirubinemia with or without bilirubin encephalopathy and the vast majority reside in sub-Saharan Africa and South Asia. Strategies and information on determinants of neonatal jaundice in sub-Saharan Africa are limited. So, investigating determinant factors of neonatal jaundice has paramount importance in mitigating jaundice-related neonatal morbidity and mortality. . Hospital-based unmatched case-control study was conducted by reviewing medical charts of 272 neonates in public general hospitals of the central zone of Tigray, northern Ethiopia. The sample size was calculated using Epi Info version 7.2.2.12, and participants were selected using a simple random sampling technique. One year medical record documents were included in the study. Data were collected through a data extraction format looking on the cards. Data were entered to the EpiData Manager version 4.4.2.1 and exported to SPSS version 20 for analysis. Descriptive and multivariate analysis was performed. Binary logistic regression was used to test the association between independent and dependent variables. Variables at value less than 0.25 in bivariate analysis were entered to a multivariable analysis to identify the determinant factors of jaundice. The level of significance was declared at value <0.05.
A total of 272 neonatal medical charts were included. Obstetric complication (AOR: 5.77; 95% CI: 1.85-17.98), low birth weight (AOR: 4.27; 95% CI:1.58-11.56), birth asphyxia (AOR: 4.83; 95% CI: 1.617-14.4), RH-incompatibility (AOR: 5.45; 95% CI: 1.58-18.74), breastfeeding (AOR: 6.11; 95% CI: 1.71-21.90) and polycythemia (AOR: 7.32; 95% CI: 2.51-21.311) were the determinants of neonatal jaundice.
Obstetric complication, low birth weight, birth asphyxia, RH-incompatibility, breastfeeding, and polycythemia were among the determinants of neonatal jaundice. Hence, early prevention and timely treatment of neonatal jaundice are important since it was a cause of long-term complication and death in neonates.
新生儿黄疸是全球范围内常见的临床问题。在全球范围内，每年约有 110 万名婴儿出现严重的高胆红素血症，伴有或不伴有胆红素脑病，其中绝大多数居住在撒哈拉以南非洲和南亚。撒哈拉以南非洲关于新生儿黄疸决定因素的策略和信息有限。因此，调查新生儿黄疸的决定因素对于减轻黄疸相关的新生儿发病率和死亡率至关重要。
本研究是在埃塞俄比亚北部提格雷中央区的公立医院中进行的一项基于医院的非匹配病例对照研究，共回顾了 272 名新生儿的病历。使用 Epi Info 版本 7.2.2.12 计算样本量，并使用简单随机抽样技术选择参与者。研究纳入了一年的病历记录。通过查看卡片上的数据提取格式收集数据。数据输入到 EpiData Manager 版本 4.4.2.1 并导出到 SPSS 版本 20 进行分析。进行描述性和多变量分析。二项逻辑回归用于检验自变量和因变量之间的相关性。在双变量分析中 值小于 0.25 的变量被纳入多变量分析，以确定黄疸的决定因素。显著性水平定义为 值 <0.05。
共纳入 272 份新生儿病历。产科并发症（OR：5.77；95%CI：1.85-17.98）、低出生体重（OR：4.27；95%CI：1.58-11.56）、出生窒息（OR：4.83；95%CI：1.617-14.4）、RH 不兼容（OR：5.45；95%CI：1.58-18.74）、母乳喂养（OR：6.11；95%CI：1.71-21.90）和红细胞增多症（OR：7.32；95%CI：2.51-21.311）是新生儿黄疸的决定因素。
产科并发症、低出生体重、出生窒息、RH 不兼容、母乳喂养和红细胞增多症是新生儿黄疸的决定因素。因此，早期预防和及时治疗新生儿黄疸非常重要，因为它是新生儿长期并发症和死亡的原因。
