Larsen M J, Fejerskov O
Scand J Dent Res. 1977 Jul;85(5):320-6. doi: 10.1111/j.1600-0722.1977.tb01510.x.
Intact enamel surfaces were exposed to 20 ml of 0.1% HCl for various periods. When the acid was unsaturated with respect to both hydroxyapatite and fluorapatite the surface enamel was etched away. With time the liquid close to the enamel became supersaturated with respect to fluorapatite but remained unsaturated with respect to hydroxyapatite. Under this condition subsurface lesions developed. These observations are discussed with reference to the use of diffusion-restricting agents in laboratory caries experiments.
完整的牙釉质表面暴露于20毫升0.1%的盐酸中不同时长。当酸对于羟基磷灰石和氟磷灰石均不饱和时，表面牙釉质被蚀刻掉。随着时间推移，靠近牙釉质的液体对于氟磷灰石变得过饱和，但对于羟基磷灰石仍不饱和。在这种情况下，牙釉质下病变形成。参照在实验室龋齿实验中使用扩散限制剂对这些观察结果进行了讨论。
