Iqbal M J, Colletta A A, Valyani S H
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, England.
Anticancer Res. 1987 Jul-Aug;7(4B):773-9.
Despite the overemphasis on sex-steroid receptors in cancer, the latter remains a multifactorial process. Many hypotheses have been put forward for the interaction of steroids with receptors but relatively little attention has been paid to other binding components, e.g., antioestrogen binding sites, intracellular sex hormone binding globulin, calcium-calmodulin, protein kinases and other receptor-independent phenomena, which may be pertinent to malignancy and are reviewed in this article.
尽管在癌症研究中对性类固醇受体存在过度强调，但癌症仍是一个多因素过程。关于类固醇与受体的相互作用已提出了许多假说，但对于其他结合成分，如抗雌激素结合位点、细胞内性激素结合球蛋白、钙调蛋白、蛋白激酶以及其他与受体无关的现象，关注相对较少，而这些现象可能与恶性肿瘤相关，本文将对此进行综述。
