慢性中性粒细胞白血病患者并发的B淋巴细胞母细胞白血病。
B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia.
作者信息
Boddy Craig S, Tan Brent T, Aoki Joseph
机构信息
Department of Oncology, Hawaii Pacific Health, Honolulu, HI.
Deprtment of Pathology, Stanford Hospital and Clinics, Stanford, CA; and.
出版信息
Blood Adv. 2020 Nov 10;4(21):5389-5392. doi: 10.1182/bloodadvances.2020003109.
Abstract
We report the first identified case of chronic neutrophilic leukemia with transformation to B-lymphoblastic leukemia. Genetic alterations involving CSF3R, ASXL1, SRSF2, and RUNX1 contributed to the unusual progression and may drive B-cell leukemogenesis.
摘要
我们报告了首例确诊的慢性中性粒细胞白血病转化为B淋巴细胞白血病的病例。涉及CSF3R、ASXL1、SRSF2和RUNX1的基因改变导致了这种不寻常的病程进展，并可能驱动B细胞白血病的发生。
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