下丘脑对葡萄糖稳态的调节：答案在基质中吗？
Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?
机构信息
Université de Paris, BFA, UMR 8251, CNRS, 75013 Paris, France.
Université de Paris, BFA, UMR 8251, CNRS, 75013 Paris, France.
出版信息
Cell Metab. 2020 Nov 3;32(5):701-703. doi: 10.1016/j.cmet.2020.10.003.
Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al. (2020) now report that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmeshes GABAergic neurons, is reversibly altered in diabetic rats and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.
弓状核内的神经元控制能量平衡，并代表着功能性基质，通过该基质，FGF1 发挥其抗糖尿病作用。Alonge 等人（2020 年）现在报告称，弓状神经周细胞网络的完整性发生了可逆性改变，该网络是一种包围 GABA 能神经元的细胞外基质成分，这在糖尿病大鼠中是一种改变，也是 FGF1 介导的糖尿病缓解的关键组成部分。这些新的见解揭示了神经周细胞网络如何动态地参与血糖的中枢控制。
Zotero 插件