MRC Centre for Molecular Bacteriology and Infection, Imperial College London, 14 Armstrong Rd, South Kensington, London SW7 2DD, United Kingdom.
MRC Centre for Molecular Bacteriology and Infection, Imperial College London, 14 Armstrong Rd, South Kensington, London SW7 2DD, United Kingdom.
Curr Opin Microbiol. 2020 Dec;58:130-137. doi: 10.1016/j.mib.2020.09.007. Epub 2020 Nov 2.
Despite the availability of antifungal treatments, fungal infections are still causing morbidity all around the globe with unacceptably high mortality rates. A major driver for the rising incidence of serious fungal infections is due to a substantial increase in immunocompromised individuals with autoimmune diseases, cancers and transplants. Because of growing resistance in fungus to frontline triazole antifungals and the association of fungal disease with the immunocompromised host, adjunctive host-directed therapy is seen as a promising choice to improve patient outcomes. Immunotherapeutic treatments being explored as adjunct therapies to existing antifungal treatments include cytokine therapy, monoclonal antibodies and cellular immunotherapy. In this review, we give a brief overview of potential immunotherapies and recent developments in the field, which are needed to tackle the growing problem of fungal diseases.
尽管有抗真菌治疗方法，但真菌感染仍在全球范围内导致发病率上升，死亡率高得令人无法接受。免疫功能低下人群（如自身免疫性疾病、癌症和移植患者）的大量增加，是导致严重真菌感染发病率上升的主要原因之一。由于真菌对抗真菌药物三唑类药物的耐药性不断增加，以及真菌感染与免疫功能低下宿主之间的关联，辅助性宿主导向治疗被视为改善患者预后的一种有前途的选择。作为现有抗真菌治疗方法的辅助治疗方法，正在探索的免疫治疗方法包括细胞因子治疗、单克隆抗体和细胞免疫治疗。在这篇综述中，我们简要概述了应对真菌病日益严重这一问题所需的潜在免疫疗法和该领域的最新进展。
