Dermatologist in private practice, Santiago de Chile.
Dermatol Online J. 2020 Oct 15;26(10):13030/qt9q40r8v8.
Pseudoatrophoderma colli is a rare entity described in the same time period as confluent and reticular papillomatosis of Gougerot-Carteaud and the two conditions have certain similarities. Pseudoatrophoderma colli is clinically characterized by lesions with an atrophic and wrinkled appearance, which are mainly located on the trunk and neck (hence the name colli). Few references exist in the literature and most of them are very old. Histopathological findings are nonspecific, showing mild hyperkeratosis, thinning of the stratum granulosum, and acanthosis and papillomatosis in some areas. In the papillary dermis there is vascular dilatation with a sparse inflammatory lymphohistiocytic perivascular infiltrate. Fragmentation of elastic tissue has been described only in one case. There is no specific treatment, with variable responses to diverse therapies including ultraviolet light, vitamin A, lactic acid and minocycline. We describe in detail two patients with pseudoatrophoderma colli and show histology. The first patient was treated with minocycline 100mg per day for two months and the second patient was treated with lymecycline 600mg per day for three months and 300mg per day for another two months. Both patients demonstrated a good response within the first month of treatment.
假性颈皮萎缩症是与 Gougerot-Carteaud 融合性网状乳头瘤病同时期描述的一种罕见疾病，这两种疾病有一定的相似性。假性颈皮萎缩症的临床特征是病变具有萎缩和起皱的外观，主要位于躯干和颈部（因此得名 colli）。文献中很少有参考资料，而且大多数都非常陈旧。组织病理学发现是非特异性的，表现为轻度角化过度、颗粒层变薄，以及某些区域的棘层肥厚和乳头瘤样增生。在乳头层真皮中可见血管扩张，稀疏的炎症性淋巴组织细胞围绕血管浸润。仅在一例中描述了弹性组织的碎裂。没有特定的治疗方法，对包括紫外线、维生素 A、乳酸和米诺环素在内的多种治疗方法的反应各不相同。我们详细描述了两名假性颈皮萎缩症患者，并展示了组织病理学。第一名患者每天服用米诺环素 100mg 治疗两个月，第二名患者每天服用利美环素 600mg 治疗三个月，然后每天服用 300mg 治疗两个月。两名患者在治疗的第一个月内都表现出良好的反应。
