Hasanzadeh Amir, Gholipour Behnam, Rostamnia Sadegh, Eftekhari Aziz, Tanomand Asghar, Valizadeh K Ali, Khaksar Samad, Khalilov Rovshan
Maragheh University of Medical Sciences, PO Box: 78151-55158, Maragheh, Iran.
Organic and Nano Group (ONG), Department of Chemistry, Faculty of Science, University of Maragheh, PO Box 55181-83111, Maragheh, Iran.
J Colloid Interface Sci. 2021 Mar;585:676-683. doi: 10.1016/j.jcis.2020.10.047. Epub 2020 Oct 20.
Nano-size silver particles were stabilized on the inner surfaces of urea based periodic mesoporous organosilica (Ur-PMO). Aqueous extract of Euphorbia leaves as a sustainable and green reducing agent was applied for Ag-nanoparticles growth into the Ur-PMO channels. Physical and chemical properties of organosilica materials synthesized using various techniques such as FT-IR, small-angle XRD, PXRD, FESEM, TEM, SEM-EDX and atomic absorption spectrometry (AAS) were examined. Finally, the AgNPs/Ur-PMO were investigated on cell viability assay. An in vitro cytotoxicity test using MMT assay displayed that the designed material has good biocompatibility and could be a promising candidate for biomedical applications. The results also showed that the AgNPs/Ur-PMO compounds (especially, PMO; 1.27% AgNPs) had relatively good antibacterial and antibiofilm effects. It seems that the use of these compounds in hospital environments can reduce nosocomial infections as well as reduce antibiotic-resistant bacteria.
纳米尺寸的银颗粒稳定在基于尿素的周期性介孔有机硅（Ur-PMO）的内表面上。大戟叶的水提取物作为一种可持续的绿色还原剂，用于使银纳米颗粒在Ur-PMO通道中生长。使用傅里叶变换红外光谱（FT-IR）、小角X射线衍射（XRD）、粉末X射线衍射（PXRD）、场发射扫描电子显微镜（FESEM）、透射电子显微镜（TEM）、扫描电子显微镜-能谱仪（SEM-EDX）和原子吸收光谱法（AAS）等各种技术合成的有机硅材料的物理和化学性质进行了研究。最后，对AgNPs/Ur-PMO进行了细胞活力测定研究。使用MTT法进行的体外细胞毒性试验表明，所设计的材料具有良好的生物相容性，可能是生物医学应用的有前途的候选材料。结果还表明，AgNPs/Ur-PMO化合物（特别是，PMO；1.27% AgNPs）具有相对良好的抗菌和抗生物膜作用。似乎在医院环境中使用这些化合物可以减少医院感染以及减少抗生素耐药细菌。
