在中国的病例对照研究中，四联筛查相关的血清标志物与不良妊娠结局有关。
Serum markers in quadruple screening associated with adverse pregnancy outcomes: A case-control study in China.
机构信息
Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
出版信息
Clin Chim Acta. 2020 Dec;511:278-281. doi: 10.1016/j.cca.2020.10.029. Epub 2020 Oct 24.
BACKGROUND
We assessed whether the results of quadruple screening during pregnancy are associated with an increased risk of adverse pregnancy outcomes.
METHODS
We measured serum marker concentrations using quadruple screening in the second trimester of pregnancy and analyzed the relationship between adverse perinatal outcomes and serum markers in 12,124 pregnant women. A multivariate logistic regression analysis was used to evaluate the relative risk of quadruple screening and adverse pregnancy outcomes.
RESULTS
Compared with the control group, increased concentrations of alpha-fetoprotein (AFP) and inhibin A were risk factors for preeclampsia and preterm delivery; low concentrations of unconjugated estriol and high inhibin A were risk factors for pregnancy hypertension; an increased concentration of human chorionic gonadotropin (hCG) was a risk factor for gestational diabetes mellitus; high AFP, low hCG, and high inhibin A were risk factors for low birth weight; and low AFP and high hCG were risk factors for macrosomia.
CONCLUSIONS
Quadruple screening in the second trimester of pregnancy can provide early warning signs for maternal and fetal adverse pregnancy outcomes.
背景
我们评估了孕期四联筛查的结果是否与不良妊娠结局风险增加相关。
方法
我们在妊娠中期使用四联筛查测量血清标志物浓度，并分析了 12124 名孕妇的不良围产结局与血清标志物之间的关系。采用多变量逻辑回归分析评估四联筛查与不良妊娠结局的相对风险。
结果
与对照组相比，甲胎蛋白（AFP）和抑制素 A 浓度升高是子痫前期和早产的危险因素；未结合雌三醇浓度降低和抑制素 A 浓度升高是妊娠高血压的危险因素；人绒毛膜促性腺激素（hCG）浓度升高是妊娠期糖尿病的危险因素；AFP 浓度升高、hCG 浓度降低和抑制素 A 浓度升高是低出生体重的危险因素；AFP 浓度降低和 hCG 浓度升高是巨大儿的危险因素。
结论
妊娠中期四联筛查可以为母婴不良妊娠结局提供早期预警信号。
Zotero 插件