School of Public Health, Curtin University, Perth, Western Australia, Australia
Burn Injury Research Unit, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
BMJ Open. 2020 Nov 3;10(11):e039104. doi: 10.1136/bmjopen-2020-039104.
To quantify postinjury cardiovascular-related health service use experienced by mid to older aged adults hospitalised for injury, compared with uninjured adults. Additionally, to explore the effect of beta-blocker medications on postinjury cardiovascular hospitalisations among injury patients, given the potential cardioprotective effects of beta blockers.
A retrospective cohort study using linked administrative and survey data.
Records of 35 026 injured and 60 823 uninjured matched adults aged over 45 from New South Wales, Australia, who completed the 45 and up survey.
Admission rates and cumulative lengths of stay for cardiovascular hospitalisations, and prescription rates for cardiovascular medications. Negative binomial and Cox proportional hazards regression modelling were used to generate incident rate ratios (IRRs) and HR.
Compared with the uninjured, those with injury had a 19% higher adjusted rate of postinjury cardiovascular admissions (IRR 1.19, 95% CI 1.14 to 1.25), spent 40% longer in hospital for ardiovascular disease (IRR 1.40, 95% CI 1.26 to 1.57) and had slightly higher cardiovascular prescription rates (IRR 1.04, 95% CI 1.02 to 1.06), during study follow-up. Those in the injury cohort that used beta blockers both prior to and after injury (continuous) appeared to have reduced need for post-injury cardiovascular hospitalisation (IRR 1.09, 95% CI 1.17 to 1.42) compared with those commencing on beta blockers after injury (after 30 days: IRR 1.69, 95% CI 1.37 to 2.08).
Apparent increased postinjury hospitalisation rates and prolonged length of stay related to cardiovascular disease suggest that injury patients may require clinical support for an extended period after injury. Additionally, injury patients who were on continuous beta blocker treatment appeared to have lower need for post-injury cardiovascular hospitalisations. However, the data do not allow us to draw clear conclusions and further clinical research is required.
定量比较中老年受伤住院患者与未受伤成年人在受伤后心血管相关医疗服务的使用情况。此外,鉴于β受体阻滞剂的潜在心脏保护作用,探索β受体阻滞剂对受伤患者心血管住院的影响。
使用链接的行政和调查数据进行回顾性队列研究。
来自澳大利亚新南威尔士州的 35026 名受伤和 60823 名未受伤且年龄超过 45 岁的匹配成年人的记录,他们完成了 45 岁及以上的调查。
心血管住院的入院率和累计住院时间以及心血管药物的处方率。使用负二项式和 Cox 比例风险回归模型生成发病率比(IRR)和 HR。
与未受伤者相比,受伤者受伤后心血管疾病的调整后入院率高出 19%(IRR 1.19,95%CI 1.14 至 1.25),因心血管疾病住院时间延长 40%(IRR 1.40,95%CI 1.26 至 1.57),心血管药物的处方率略高(IRR 1.04,95%CI 1.02 至 1.06),在研究随访期间。在受伤队列中,那些在受伤前后都使用(连续)β受体阻滞剂的人,与那些在受伤后开始使用β受体阻滞剂的人(30 天后:IRR 1.69,95%CI 1.37 至 2.08)相比,似乎需要受伤后更长时间的心血管住院治疗。
受伤后住院率和与心血管疾病相关的住院时间延长似乎表明,受伤患者在受伤后可能需要更长时间的临床支持。此外,持续使用β受体阻滞剂的受伤患者似乎需要更少的受伤后心血管住院治疗。然而,数据还不能让我们得出明确的结论,需要进一步的临床研究。