Department of Breast Surgery , Fukuoka Higashi Medical Center, Fukuoka, Japan.
Saiseikai Fukuoka General Hospital, Tanaka Junko Breast Clinic , Fukuoka Higashi Medical Center, Fukuoka, Japan.
J Med Invest. 2020;67(3.4):365-367. doi: 10.2152/jmi.67.365.
Spindle cell carcinoma (SpCC) of the breast is quite a rare modality classified to the metaplastic carcinoma of the breast. Regarding its biological behavior and the prognosis of the patients with this rare tumor, it has been remaining controversial. We herein report an 88 year-old woman who had a huge bleeding tumor on the right breast. She was a high-aged woman with low activities of daily life, even with some suspicion of distant organ metastasis. While the tumor proved to drastically bleed due to the tumor disintegration, a right simple mastectomy was performed. According to the histopathologic examinations, sarcomatoid spindle cells with severe atypia were observed. By an immunohistochemical examination, the tumor had proved to express neither estrogen receptor, progesterone receptor nor HER2 receptor. Moreover an immunohistochemical expression of AE1/3 and CAM5.2, defining an epithelial neoplasm were observed in addition to an expression of vimentin. From these findings, this bleeding tumor was diagnosed as spindle cell carcinoma of the breast. J. Med. Invest. 67 : 365-367, August, 2020.
乳腺梭形细胞癌（SpCC）是一种罕见的乳腺间变性癌。关于这种罕见肿瘤的生物学行为和患者预后，一直存在争议。我们在此报告一例 88 岁老年女性，右侧乳房有一个巨大的出血性肿瘤。她是一位高龄患者，日常生活活动能力较低，甚至有远处器官转移的可疑迹象。由于肿瘤破裂导致大量出血，因此进行了单纯右乳房切除术。根据组织病理学检查，观察到具有严重异型性的肉瘤样梭形细胞。通过免疫组织化学检查，肿瘤既不表达雌激素受体、孕激素受体也不表达 HER2 受体。此外，除了波形蛋白表达外，还观察到 AE1/3 和 CAM5.2 的免疫组织化学表达，这定义了一种上皮性肿瘤。根据这些发现，该出血性肿瘤被诊断为乳腺梭形细胞癌。医学研究杂志 67：365-367，2020 年 8 月。
