• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Are infections seeding some cases of Alzheimer's disease?

作者信息

Abbott Alison

出版信息

Nature. 2020 Nov;587(7832):22-25. doi: 10.1038/d41586-020-03084-9.

DOI:10.1038/d41586-020-03084-9
PMID:33149296
Abstract
摘要

相似文献

1
Are infections seeding some cases of Alzheimer's disease?感染是否引发了某些阿尔茨海默病病例?
Nature. 2020 Nov;587(7832):22-25. doi: 10.1038/d41586-020-03084-9.
2
The amyloid hypothesis on trial.正在接受检验的淀粉样蛋白假说。
Nature. 2018 Jul;559(7715):S4-S7. doi: 10.1038/d41586-018-05719-4.
3
Towards development of drugs targeting both amyloid and tau pathologies of Alzheimer's disease.致力于开发针对阿尔茨海默病淀粉样蛋白和tau蛋白病变的药物。
Int J Geriatr Psychiatry. 2011 May;26(5):546-8. doi: 10.1002/gps.2543.
4
infection may contribute to systemic and intracerebral amyloid-beta: implications for Alzheimer's disease onset.感染可能促成全身性和脑内β-淀粉样蛋白:对阿尔茨海默病发病的影响。
Expert Rev Anti Infect Ther. 2020 Nov;18(11):1063-1066. doi: 10.1080/14787210.2020.1792292. Epub 2020 Jul 14.
5
Frustrated Alzheimer's researchers seek better lab mice.受挫的阿尔茨海默病研究人员在寻找更好的实验小鼠。
Nature. 2018 Nov;563(7733):611-612. doi: 10.1038/d41586-018-07484-w.
6
Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases.神经退行性疾病中的糖胺聚糖与β-淀粉样蛋白、朊病毒和tau蛋白肽
Peptides. 2002 Jul;23(7):1323-32. doi: 10.1016/s0196-9781(02)00068-2.
7
HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.组蛋白去乙酰化酶 3 负调控阿尔茨海默病小鼠模型的空间记忆。
Aging Cell. 2017 Oct;16(5):1073-1082. doi: 10.1111/acel.12642. Epub 2017 Aug 3.
8
Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer's Disease.分子洞察类黄酮治疗阿尔茨海默病的潜力。
Molecules. 2020 Mar 11;25(6):1267. doi: 10.3390/molecules25061267.
9
in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.在阿尔茨海默病患者大脑中:用小分子抑制剂治疗疾病的因果证据。
Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.
10
Pioneering Alzheimer's study in Colombia zeroes in on enigmatic protein.哥伦比亚一项开创性的阿尔茨海默病研究聚焦于神秘蛋白质。
Nature. 2018 Mar 29;555(7698):567-568. doi: 10.1038/d41586-018-03848-4.

引用本文的文献

1
Comparison of safety of lecanemab and aducanumab: a real-world disproportionality analysis using the FDA adverse event reporting system.莱卡奈单抗与阿杜卡奴单抗安全性比较:一项使用美国食品药品监督管理局不良事件报告系统的真实世界不成比例性分析。
Front Pharmacol. 2025 May 30;16:1593989. doi: 10.3389/fphar.2025.1593989. eCollection 2025.
2
Bacteria in the brain: do they have a role in the pathogenesis of Alzheimer's disease?大脑中的细菌:它们在阿尔茨海默病的发病机制中起作用吗?
Curr Opin Psychiatry. 2025 May 1;38(3):252-257. doi: 10.1097/YCO.0000000000000989. Epub 2025 Feb 27.
3
The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review.

本文引用的文献

1
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.先天免疫蛋白 IFITM3 调节阿尔茨海默病中的 γ-分泌酶。
Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2.
2
Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts.在多个队列的阿尔茨海默病病例和对照中检测人类疱疹病毒 6。
Neuron. 2020 Mar 18;105(6):1027-1035.e2. doi: 10.1016/j.neuron.2019.12.031. Epub 2020 Jan 23.
3
Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.
遗传、环境和饮食因素在阿尔茨海默病中的作用:一项叙述性综述
Int J Mol Sci. 2025 Jan 30;26(3):1222. doi: 10.3390/ijms26031222.
4
Untangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia.利用高通量RNA测序数据和新一代知识发现方法解析老年患者阿尔茨海默病的复杂机制:聚焦痴呆潜在基因特征和药物
Heliyon. 2024 Dec 18;11(1):e41266. doi: 10.1016/j.heliyon.2024.e41266. eCollection 2025 Jan 15.
5
Helicobacter pylori outer membrane vesicles directly promote Aβ aggregation and enhance Aβ toxicity in APP/PS1 mice.幽门螺杆菌外膜囊泡直接促进 Aβ 聚集,并增强 APP/PS1 小鼠中的 Aβ 毒性。
Commun Biol. 2024 Nov 9;7(1):1474. doi: 10.1038/s42003-024-07125-1.
6
Severe infections as a gateway to dementia.严重感染是引发痴呆症的一个途径。
Nat Aging. 2024 Jun;4(6):752-754. doi: 10.1038/s43587-024-00643-x.
7
Novel technologies uncover novel 'anti'-microbial peptides in shaping the species-specific microbiome.新型技术在塑造物种特异性微生物组方面揭示了新型的“抗”微生物肽。
Philos Trans R Soc Lond B Biol Sci. 2024 May 6;379(1901):20230058. doi: 10.1098/rstb.2023.0058. Epub 2024 Mar 18.
8
The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer's disease?口腔-脑轴:牙周病原体能否引发阿尔茨海默病的发生和发展?
Front Microbiol. 2024 Feb 1;15:1358179. doi: 10.3389/fmicb.2024.1358179. eCollection 2024.
9
Amyloid and Tau as cerebrospinal fluid biomarkers in anti-N-Methyl-D-aspartate receptor encephalitis.抗 N-甲基-D-天冬氨酸受体脑炎中的淀粉样蛋白和 Tau 作为脑脊液生物标志物。
Neurol Sci. 2024 Jul;45(7):3399-3410. doi: 10.1007/s10072-024-07341-x. Epub 2024 Jan 27.
10
Secrets and lies of host-microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases.宿主-微生物相互作用的秘密和谎言:MHC 限制和 T 细胞迁移的反调节掩盖了微生物因子在健康和多因素/复杂疾病之间边缘的作用。
Cell Mol Life Sci. 2024 Jan 13;81(1):40. doi: 10.1007/s00018-023-05040-y.
疱疹病毒科可快速引发与阿尔茨海默病相关的β-淀粉样蛋白生成,以预防脑部感染。
Neuron. 2018 Dec 19;100(6):1527-1532. doi: 10.1016/j.neuron.2018.11.043.
4
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.配对免疫球蛋白样受体 2 型α G78R 变体改变配体结合并赋予阿尔茨海默病保护作用。
PLoS Genet. 2018 Nov 2;14(11):e1007427. doi: 10.1371/journal.pgen.1007427. eCollection 2018 Nov.
5
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.多尺度分析独立的阿尔茨海默病队列发现人类疱疹病毒破坏分子、遗传和临床网络。
Neuron. 2018 Jul 11;99(1):64-82.e7. doi: 10.1016/j.neuron.2018.05.023. Epub 2018 Jun 21.
6
Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan.抗疱疹药物与单纯疱疹病毒感染者痴呆风险降低的关联:一项基于台湾全国人群队列的研究
Neurotherapeutics. 2018 Apr;15(2):417-429. doi: 10.1007/s13311-018-0611-x.
7
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.在阿尔茨海默病的小鼠和线虫模型中,β淀粉样肽可抵御微生物感染。
Sci Transl Med. 2016 May 25;8(340):340ra72. doi: 10.1126/scitranslmed.aaf1059.
8
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.阿尔茨海默病相关的淀粉样β蛋白是一种抗菌肽。
PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.
9
Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains.正常大脑和阿尔茨海默病大脑中的潜伏性单纯疱疹病毒1型
J Med Virol. 1991 Apr;33(4):224-7. doi: 10.1002/jmv.1890330403.