Mahesh Jagadeson, Veeresh Dummi J, Akhil Pallepati, Vishnuprasad Subramanian, Premkumar Srinivasan, Shaswata Karmakar
Department of Public Health Dentistry, Karpaga Vinayaga Institute of Dental Sciences, Madhuranthagam, Tamilnadu, India.
Department of Public Health Dentistry, Bapuji Dental college and Hospital, Davangere, Karnataka, India.
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S182-S189. doi: 10.4103/jpbs.JPBS_54_20. Epub 2020 Aug 28.
There is an increase in longevity of teeth retained in elderly population, leading to increased risk of root caries. Therefore, new and affordable preventive strategies are in need to reduce this problem. Hence, the aim and objective of the study was to assess and compare the root caries remineralization effect of plain milk, 5ppm of fluoridated milk, and 5ppm of NaF in deionized water.
The study was an experimental design. Sixty root samples were divided into five groups (sound root, demineralized root treated in deionized water, plain milk, 5-ppm fluoridated milk, and 5-ppm fluoridated deionized water) of 12 samples each after baseline surface microhardness analysis and standardization was carried out in the study. All groups except the sound root were subjected to demineralization procedure for 4 days at 37°C. The demineralized four groups were treated to test solutions and subjected to pH cycling for 14 days. This was followed with assessment of postintervention surface microhardness. Student's paired test was used for comparing surface within groups. One-way analysis of variance test and Tukey's test were conducted for between groups' comparison.
There was a significant difference between groups ( < 0.05). The results of showed that significant difference was found between the group sound root and demineralized treated with 5-ppm fluoridated milk and 5-ppm fluoridated deionized water with an effect size of 2.15 and 2.87, with CI (-26.8 to -8.1) and (-36 to -17.3), respectively. There was a significant difference in all the groups when compared within the group ( < 0.05).
Plain milk, 5-ppm fluoridated milk, and 5-ppm fluoridated deionized water showed remineralizing potential against demineralized root caries samples. 5-ppm fluoridated deionized water and 5-ppm fluoridated milk have a better effect compared to plain milk.
老年人群中保留牙齿的寿命有所增加，导致根龋风险上升。因此，需要新的且经济实惠的预防策略来减少这一问题。因此，本研究的目的是评估和比较纯牛奶、5ppm氟化牛奶以及5ppm氟化钠去离子水对根龋的再矿化效果。
本研究采用实验设计。在进行基线表面显微硬度分析和标准化后，将60个牙根样本分为五组（健康牙根、在去离子水中处理的脱矿牙根、纯牛奶、5ppm氟化牛奶和5ppm氟化去离子水），每组12个样本。除健康牙根组外，所有组在37°C下进行4天的脱矿处理。对脱矿的四组进行测试溶液处理，并进行14天的pH循环。随后评估干预后表面显微硬度。采用学生配对检验比较组内表面情况。采用单因素方差分析和Tukey检验进行组间比较。
组间存在显著差异（<0.05）。结果表明，健康牙根组与用5ppm氟化牛奶和5ppm氟化去离子水处理的脱矿组之间存在显著差异，效应大小分别为2.15和2.87，置信区间分别为（-26.8至-8.1）和（-36至-17.3）。组内比较时，所有组均存在显著差异（<0.05）。
纯牛奶、5ppm氟化牛奶和5ppm氟化去离子水对脱矿的根龋样本显示出再矿化潜力。与纯牛奶相比，5ppm氟化去离子水和5ppm氟化牛奶效果更好。
