中国妇科癌肉瘤患者预后因素的研究 妇科癌肉瘤的预后
A Study of Prognostic Factors of Chinese Patients with Gynecologic Tract Carcinosarcomas Prognosis of Gynecologic Carcinosarcomas.
作者信息
Ye Dan, Shen Hao-Ran, Yao Liangqing
机构信息
Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People's Republic of China.
出版信息
Cancer Manag Res. 2020 Oct 29;12:10781-10788. doi: 10.2147/CMAR.S267128. eCollection 2020.
BACKGROUND
Thinking of the rarity and malignancy of gynecologic tract carcinosarcomas (GTCS), the aim of the study was to investigate the possible predictors of relapse-free survival (RFS) and overall survival (OS) for GTCS patients.
METHODS
We performed a retrospective cohort study of women with GTCS at our hospital between January 2009 and December 2013. We used the Kaplan-Meier method to calculate RFS and OS, and Cox regression analysis to define the survival effects of risk factors.
RESULTS
A total of 45 GTCS patients were included in the study. The median follow-up time was 46 months. Cox regression analysis showed that lymph node metastasis was significantly associated with worse RFS (HR: 3.145; 95%CI: 1.181-8.378; =0.022) and OS (HR: 4.065; 95%CI: 1.57-10.524; =0.004). Pelvic lymphadenectomy had a favorable RFS (HR: 0.213; 95%CI: 0.057-0.796; = 0.021).
CONCLUSION
Lymph node metastasis significantly affected the prognosis of uterine carcinosarcoma. Pelvic lymphadenectomy could reduce the relapse rate of GTCS patients.
背景
考虑到妇科癌肉瘤（GTCS）的罕见性和恶性程度，本研究旨在探讨GTCS患者无复发生存期（RFS）和总生存期（OS）的可能预测因素。
方法
我们对2009年1月至2013年12月期间我院收治的GTCS女性患者进行了一项回顾性队列研究。我们使用Kaplan-Meier方法计算RFS和OS，并通过Cox回归分析确定危险因素对生存的影响。
结果
本研究共纳入45例GTCS患者。中位随访时间为46个月。Cox回归分析显示，淋巴结转移与较差的RFS（HR：3.145；95%CI：1.181-8.378；P=0.022）和OS（HR：4.065；95%CI：1.57-10.524；P=0.004）显著相关。盆腔淋巴结清扫术对RFS有良好影响（HR：0.213；95%CI：0.057-0.796；P = 0.021）。
结论
淋巴结转移显著影响子宫癌肉瘤的预后。盆腔淋巴结清扫术可降低GTCS患者的复发率。
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