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β 型转化生长因子受体 3 单倍型与镰状细胞病的血脂谱和临床表现有关。

Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations.

机构信息

Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, Brazil.

Universidade Federal da Bahia, UFBA, Salvador 40170-110, Brazil.

出版信息

Mediators Inflamm. 2020 Oct 13;2020:3185015. doi: 10.1155/2020/3185015. eCollection 2020.

DOI:10.1155/2020/3185015
PMID:33149723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7603616/
Abstract

Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF- pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 () gene have been linked to several inflammatory diseases. This study investigated associations between two haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of present important alterations in lipid profile.

摘要

患有镰状细胞病 (SCD) 的个体表现出慢性和急性炎症事件。TGF-途径已知在免疫反应、血管生成、炎症、造血、血管炎症和细胞增殖中发挥作用。转化生长因子-β受体 3 () 基因中的多态性与几种炎症性疾病有关。本研究调查了两个 单倍型与 SCD 中的经典实验室参数以及临床表现之间的关联。我们发现，与非 GG 单倍型相比，具有 GG 单倍型的个体总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL-C)、甘油三酯、非高密度脂蛋白胆固醇、总蛋白和球蛋白水平更高。此外，GG 单倍型与肺炎的既往病史有关。具有 CGG 单倍型的个体血小板比容、TC、LDL-C 水平和非高密度脂蛋白胆固醇升高。CCG 单倍型也与肺炎的既往病史有关。我们的研究结果表明，具有 GG 和 CGG 单倍型的个体血脂谱发生重要改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/ab2470f4a5d6/MI2020-3185015.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/73d908e2ad32/MI2020-3185015.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/a788c8244452/MI2020-3185015.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/296621b862f0/MI2020-3185015.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/954b83ede366/MI2020-3185015.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/ab2470f4a5d6/MI2020-3185015.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/73d908e2ad32/MI2020-3185015.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/a788c8244452/MI2020-3185015.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/296621b862f0/MI2020-3185015.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/954b83ede366/MI2020-3185015.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caf/7603616/ab2470f4a5d6/MI2020-3185015.005.jpg

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