Zhou Guang-Peng, Sun Li-Ying, Zhu Zhi-Jun
Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University; and Clinical Center for Pediatric Liver Transplantation, Capital Medical University; No. 95 Yong-an Road, Xi-Cheng District, Beijing 100050, China.
Therap Adv Gastroenterol. 2020 Oct 24;13:1756284820968755. doi: 10.1177/1756284820968755. eCollection 2020.
Although orthotopic liver transplantation remains the only proven treatment for end-stage liver disease and inherited metabolic liver disease, its application has been limited by the scarcity of donor organs available for transplantation. Among feasible approaches developed to expand the donor organ pool, domino liver transplantation is a strategy in which explanted genetically defective livers of liver transplant recipients are used as grafts in other patients. Another promising therapeutic strategy is hepatocyte transplantation, an alternative to liver transplantation for certain groups of patients. However, the availability of primary hepatocytes is also hindered by the shortage of donor liver tissues. Against this background, domino hepatocyte transplantation, a strategy that utilizes the hepatocytes derived from the explanted livers of liver transplant recipients with noncirrhotic inherited metabolic liver diseases as the source of primary hepatocytes, may help increase the supply of liver cells available for transplantation. In this review, we focus on the of domino liver transplantation and domino hepatocyte transplantation. We also describe recent innovative transplant strategies based on domino transplantation.
尽管原位肝移植仍然是治疗终末期肝病和遗传性代谢性肝病的唯一经证实的疗法，但其应用一直受到可用于移植的供体器官稀缺的限制。在为扩大供体器官库而开发的可行方法中，多米诺肝移植是一种策略，即肝移植受者切除的基因缺陷肝脏被用作其他患者的移植物。另一种有前景的治疗策略是肝细胞移植，这是某些患者群体肝移植的替代方法。然而，原代肝细胞的可获得性也受到供体肝组织短缺的阻碍。在此背景下，多米诺肝细胞移植，一种利用来自患有非肝硬化遗传性代谢性肝病的肝移植受者切除肝脏的肝细胞作为原代肝细胞来源的策略，可能有助于增加可用于移植的肝细胞供应。在本综述中，我们重点关注多米诺肝移植和多米诺肝细胞移植。我们还描述了基于多米诺移植的近期创新移植策略。
