Budisteanu Magdalena, Andrei Emanuela, Linca Florentina, Hulea Diana Stefania, Velicu Alexandra Catalina, Mihailescu Ilinca, Riga Sorin, Arghir Aurora, Papuc Sorina Mihaela, Sirbu Carmen Adella, Mitrica Marian, Docu-Axelerad Any, Ghinescu Minerva Claudia, Dobrescu Iuliana, Rad Florina
Psychiatry Research Laboratory, 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry, 041914 Bucharest, Romania.
Medical Genetics Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Exp Ther Med. 2020 Dec;20(6):210. doi: 10.3892/etm.2020.9340. Epub 2020 Oct 14.
Schizophrenia is a neurodevelopmental disorder, characterized by impairment in reasoning, affectivity and social relationships. Although the diagnosis of schizophrenia in children and adolescents has been challenged for many years, at present childhood-onset schizophrenia is considered and accepted as a clinical and biological continuum with the adult-onset disorder. The present study aimed to evaluate the influence of biological (psychiatric family history, perinatal factors), and socio-demographic factors (area of residence, gender) on the age at onset and severity of symptomatology in children and adolescent with schizophrenia. The data were collected from 2016 to 2019 and included 148 children and adolescents with schizophrenia. Data were analysed with statistical software (IBM SPSS 22, JASP and JAMOVI, Linear Regression Model, χ² tests, t-test, U-test). A positive familial history for psychiatric diseases was an important risk factor both for an early onset and for the severity of symptoms. Urbanicity was another studied risk factor, 61% of patients being from urban areas; no statistically significant correlations between urbanicity and age at onset and severity of symptoms were identified. There was no statistically significant gender difference in terms of age at onset and severity of symptoms. Moreover, no statistically significant correlations were found between perinatal factors and age at onset and severity of symptoms. Positive psychiatric family history showed a statistically significant influence on age at onset and symptoms severity in children and adolescent schizophrenia; no statistical significant impact on the aforementioned schizophrenia aspects was observed for urbanicity, gender or perinatal factors.
精神分裂症是一种神经发育障碍，其特征是推理、情感和社会关系受损。尽管儿童和青少年精神分裂症的诊断多年来一直受到质疑，但目前儿童期起病的精神分裂症被认为并被接受为与成人期起病的疾病具有临床和生物学连续性。本研究旨在评估生物学因素（精神疾病家族史、围产期因素）和社会人口学因素（居住地区、性别）对儿童和青少年精神分裂症起病年龄和症状严重程度的影响。数据收集于2016年至2019年，包括148名儿童和青少年精神分裂症患者。使用统计软件（IBM SPSS 22、JASP和JAMOVI、线性回归模型、χ²检验、t检验、U检验）对数据进行分析。精神疾病的阳性家族史是起病早和症状严重程度的重要危险因素。城市化是另一个研究的危险因素，61%的患者来自城市地区；未发现城市化与起病年龄和症状严重程度之间存在统计学上的显著相关性。在起病年龄和症状严重程度方面，未发现性别存在统计学上的显著差异。此外，未发现围产期因素与起病年龄和症状严重程度之间存在统计学上的显著相关性。精神疾病阳性家族史对儿童和青少年精神分裂症的起病年龄和症状严重程度有统计学上的显著影响；城市化、性别或围产期因素对上述精神分裂症方面未观察到统计学上的显著影响。
