胰腺腺泡细胞内的钙离子：酶分泌刺激中的调节与作用

Intracellular Ca2+ in pancreatic acinar cells: regulation and role in stimulation of enzyme secretion.

作者信息

Dormer R L, Brown G R, Doughney C, McPherson M A

机构信息

Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK.

出版信息

Biosci Rep. 1987 Apr;7(4):333-44. doi: 10.1007/BF01121455.

DOI:10.1007/BF01121455

PMID:3315027

Abstract

Evidence for a primary role for intracellular Ca2+ in the stimulation of pancreatic enzyme secretion is reviewed. Measurements of cytoplasmic free Ca2+ concentration have allowed direct demonstration of its importance in triggering enzyme secretion and defined the concentration range over which membrane Ca2+ pumps must work to regulate intracellular Ca2+. Current evidence suggests a key role for the Ca2+, Mg-ATPase of rough endoplasmic reticulum in regulating intracellular Ca2+ and accumulating a Ca2+ store which is released by the action of inositol-1,4,5 trisphosphate following stimulation of secretion.

摘要

本文综述了细胞内钙离子在刺激胰腺酶分泌中起主要作用的证据。细胞质游离钙离子浓度的测量直接证明了其在触发酶分泌中的重要性，并确定了膜钙离子泵调节细胞内钙离子所必须工作的浓度范围。目前的证据表明，粗面内质网的钙离子、镁 - 三磷酸腺苷酶在调节细胞内钙离子以及积累一个在分泌刺激后由肌醇 - 1,4,5 - 三磷酸作用释放的钙离子储存库方面起着关键作用。