人红细胞膜对肌醇1,3,4,5-四磷酸的代谢。肌醇1,4,5-三磷酸形成的新机制。
Metabolism of inositol 1,3,4,5-tetrakisphosphate by human erythrocyte membranes. A new mechanism for the formation of inositol 1,4,5-trisphosphate.
作者信息
Doughney C, McPherson M A, Dormer R L
机构信息
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, U.K.
出版信息
Biochem J. 1988 May 1;251(3):927-9. doi: 10.1042/bj2510927.
Abstract
Human erythrocyte membranes metabolize inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] to inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] in the presence of Mg2+. In the absence of Mg2+ a less rapid conversion of Ins(1,3,4,5)P4 into Ins(1,4,5)P3 was revealed. Such an enzyme activity, if present in hormonally sensitive cells, could provide a mechanism for maintaining constant concentrations of Ins(1,4,5)P3 and Ins(1,3,4,5)P4, important for stimulation of Ca2+ entry after Ca2+ mobilization.
摘要
在镁离子存在的情况下，人红细胞膜可将1,3,4,5 - 四磷酸肌醇[Ins(1,3,4,5)P4]代谢为1,3,4 - 三磷酸肌醇[Ins(1,3,4)P3]。在没有镁离子的情况下，Ins(1,3,4,5)P4向Ins(1,4,5)P3的转化速度较慢。如果这种酶活性存在于激素敏感细胞中，可能为维持Ins(1,4,5)P3和Ins(1,3,4,5)P4的恒定浓度提供一种机制，这对于钙离子动员后刺激钙离子内流很重要。
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