增加从头合成谷胱甘肽可增强被剥夺异相睡眠的大鼠的性功能障碍。

Increased de novo glutathione production enhances sexual dysfunctions in rats subjected to paradoxical sleep deprivation.

机构信息

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.

Department of Anatomy, Faculty of Basic Medical Sciences, Gregory University, Uturu, Anabra State, Nigeria.

出版信息

JBRA Assist Reprod. 2021 Apr 27;25(2):215-222. doi: 10.5935/1518-0557.20200070.

DOI:10.5935/1518-0557.20200070

PMID:33150783

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083868/

Abstract

OBJECTIVE

Poor quality of sexual life has been reported secondary to poor sleep or sleep deprivation. Paradoxical sleep is an integral part of the sleep-wakefulness physiology and prolonged paradoxical sleep deprivation (PSD) may even be fatal. The objective of this investigation was to determine if D-ribose-L-cysteine (RibCys) and zinc (Zn) administration can attenuate the effect of PSD on the sexual function of male rats.

METHODS

Following acclimatization, 25 male rats were randomly distributed into five groups of 5 rats each. The PSD, PSD+RibCys, PSD+Zn, PSD+RibCys+Zn, and Control groups were sleep-deprived only, sleep-deprived and given 100mg/kg body-weight of pure RibCys, sleep-deprived and given 10mg/kg body weight Zn, sleep-deprived and given a combination of 100mg/kg of RibCys and 10mg/kg of Zn, and given distilled water without sleep deprivation, respectively. PSD lasted for 20 hours per day for 14 days. Subsequently, the sexual behavioral study was carried out and the animals were sacrificed for biochemical assays.

RESULTS

Analyses of results show that for animals treated with RibCys or Zn, all sexual parameters such as mount frequency and latency, intromission frequency and latency and ejaculation frequency and latency were significantly improved compared with animals subjected to PSD only. This improvement correlates strongly with serum glutathione (GHS) levels.

CONCLUSION

In summary, riboceine increases circulating GHS, which leads to improved sexual function during sleep deprivation.

摘要

目的

据报道，睡眠质量差或睡眠剥夺会导致性生活质量下降。异相睡眠是睡眠-觉醒生理的一个组成部分，而长时间的异相睡眠剥夺（PSD）甚至可能是致命的。本研究的目的是确定 D-核糖-L-半胱氨酸（RibCys）和锌（Zn）的给药是否可以减轻 PSD 对雄性大鼠性功能的影响。

方法

适应环境后，将 25 只雄性大鼠随机分为 5 组，每组 5 只。PSD、PSD+RibCys、PSD+Zn、PSD+RibCys+Zn 和对照组仅睡眠剥夺，睡眠剥夺并给予 100mg/kg 体重的纯 RibCys，睡眠剥夺并给予 10mg/kg 体重的 Zn，睡眠剥夺并给予 100mg/kg 的 RibCys 和 10mg/kg 的 Zn 的组合，以及给予不含睡眠剥夺的蒸馏水，分别给予。PSD 每天持续 20 小时，持续 14 天。随后进行性行为研究，并对动物进行生化分析。