Rice G P
Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada.
Can J Neurol Sci. 1987 Aug;14(3 Suppl):510-2. doi: 10.1017/s0317167100038014.
The availability of new antispasticity agents has greatly extended the therapeutic arm of the neurologist and has obviated the need for destructive neurosurgical procedures in many instances. Baclofen remains the single most useful agent, but in certain circumstances, benzodiazepines and dantrolene sodium are useful alternative or adjunctive treatments. Tizanidine has been recently introduced, and early experience with this agent appears to be favourable. A variety of new drugs are awaiting further evaluation. The effective use of these agents demands an understanding of their principal mechanisms of action, knowledge of their predictable side effects, and a familiarity with the underlying neurological disorders. The monitoring of clinical efficacy is difficult and is often dependent upon subjective evaluation. The application of electrophysiological studies might facilitate the monitoring of treatment and the prediction of optimum treatment strategies for individual patients. The use of these pharmacological agents, from the perspective of a clinician, will be discussed.
新型抗痉挛药物的出现极大地扩展了神经科医生的治疗手段，并且在许多情况下不再需要进行破坏性的神经外科手术。巴氯芬仍然是最有用的单一药物，但在某些情况下，苯二氮䓬类药物和丹曲林钠是有用的替代或辅助治疗药物。替扎尼定最近已被引入，早期使用该药的经验似乎良好。多种新药正在等待进一步评估。有效使用这些药物需要了解其主要作用机制、知晓其可预测的副作用，并熟悉潜在的神经系统疾病。临床疗效的监测很困难，且往往依赖主观评估。电生理研究的应用可能有助于治疗监测以及为个体患者预测最佳治疗策略。本文将从临床医生的角度讨论这些药物的使用。
