Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
PLoS One. 2020 Nov 5;15(11):e0241494. doi: 10.1371/journal.pone.0241494. eCollection 2020.
Full endoscopic lumbar discectomy (FELD) for lumbar disc herniation (LDH) has become popular in recent years. Previous studies have proven the efficacy, but few have discussed the possible risk factors of poor outcome. In this study, we reviewed patients who underwent FELD at Changhua Christian Hospital in the past 10 years and sought to identify factors associated with poor surgical outcomes and re-operations.
We retrospectively reviewed records from mid-2009 to mid-2018. Patients had undergone FELD and follow-up for ≥1 year were included. Factors included in the outcome evaluations were age, sex, surgical time, body mass index, surgical methods, disc herniation type, extension of herniation, degree of canal compromised, disc degenerative grade, smoking and alcohol use, surgical lumbar level, symptom duration, Oswestry low back disability index, and visual analog scale score. We had evolved from inside-out methods to outside-in methods after 2016, thus, we included this factor in the analysis. The primary outcomes of interest were poor/fair MacNab score and re-operation.
From mid-2009 to mid-2018, 521 patients met our criteria and were analyzed. The median follow-up was 1685 days (range, 523-3923 days). Thirty-one (6.0%) patients had poor surgical outcomes (fair/poor MacNab score) and 45 (8.6%) patients required re-operation. Prolapsed herniated disc (P < 0.001), higher disc degenerative grade (P = 0.047), higher lumbar level (P = 0.026), longer preoperative symptoms (P < 0.001), and surgery before 2017 (outside-in technique, P = 0.020) were significant factors associated with poor outcomes in univariate analyses. In multivariate analyses, prolapsed herniated disc (P < 0.001), higher disc degenerative grade (P = 0.030), and higher lumbar level (P = 0.046) were statistically significant. The most common adverse symptom was numbness. Factors possibly associated with higher re-operation rate were older age (P = 0.045), alcohol use (P = 0.073) and higher lumbar level (P = 0.069). Only alcohol use showed statistically significant re-operation rates in multivariate analyses (P = 0.035).
For treating LDH by FELD, we concluded that prolapsed disc, higher disc degenerative grade, higher lumbar level, and longer preoperative symptom duration were possibly associated with unsatisfactory surgical outcomes (poor/fair MacNab score). The outside-in technique might be superior to the inside-out technique. Older age and alcohol use might be associated with a higher re-operation rate.
全内镜下腰椎间盘切除术(FELD)治疗腰椎间盘突出症(LDH)近年来越来越受欢迎。先前的研究已经证明了其疗效,但很少有研究讨论可能导致手术效果不佳和需要再次手术的风险因素。在这项研究中,我们回顾了过去 10 年在彰化基督教医院接受 FELD 的患者,并试图确定与手术结果不佳和再次手术相关的因素。
我们回顾性分析了 2009 年年中至 2018 年年中的记录。纳入接受 FELD 并随访≥1 年的患者。结局评估中包括的因素包括年龄、性别、手术时间、体重指数、手术方法、椎间盘突出类型、突出延伸程度、椎管受压程度、椎间盘退行性分级、吸烟和饮酒史、手术腰椎节段、症状持续时间、Oswestry 下腰痛残疾指数和视觉模拟评分。2016 年后,我们从内向外方法发展为从外向内方法,因此,我们将此因素纳入分析。主要观察指标为手术效果差/一般的 MacNab 评分和再次手术。
2009 年年中至 2018 年年中,共有 521 名符合标准的患者被纳入分析。中位随访时间为 1685 天(范围为 523-3923 天)。31 名(6.0%)患者手术效果不佳(MacNab 评分差/一般),45 名(8.6%)患者需要再次手术。椎间盘突出(P<0.001)、较高的椎间盘退行性分级(P=0.047)、较高的腰椎节段(P=0.026)、较长的术前症状持续时间(P<0.001)和 2017 年前手术(从外向内技术,P=0.020)是单因素分析中与手术效果不佳相关的显著因素。多因素分析中,椎间盘突出(P<0.001)、椎间盘退行性分级较高(P=0.030)和较高的腰椎节段(P=0.046)具有统计学意义。最常见的不良症状是麻木。可能与较高再手术率相关的因素包括年龄较大(P=0.045)、饮酒(P=0.073)和较高的腰椎节段(P=0.069)。仅饮酒在多因素分析中显示出统计学意义的再手术率(P=0.035)。
对于 FELD 治疗 LDH,我们得出结论,椎间盘突出、较高的椎间盘退行性分级、较高的腰椎节段和较长的术前症状持续时间可能与手术效果不佳(MacNab 评分差/一般)相关。从外向内技术可能优于从内向外技术。年龄较大和饮酒可能与较高的再手术率相关。