Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Centre - Albert-Ludwigs-University of Freiburg, Albert-Ludwigs-University of Freiburg, Hugstetterstrasse 55, 79106, Freiburg, Germany.
Department of Spine Surgery, Loretto Hospital, Freiburg, Germany.
Eur Spine J. 2023 Aug;32(8):2863-2874. doi: 10.1007/s00586-023-07551-5. Epub 2023 Feb 2.
Endoscopic spine surgery is a globally expanding technique advocated as less invasive for spinal stenosis treatment compared to the microsurgical approach. However, evidence on the efficiency of interlaminar full-endoscopic decompression (FED) vs. conventional microsurgical decompression (MSD) in patients with lumbar spinal stenosis is still scarce. We conducted a case-matched comparison for treatment success with consideration of clinical, laboratory, and radiologic predictors.
We included 88 consecutive patients (FED: 36/88, 40.9%; MSD: 52/88, 59.1%) presenting with lumbar central spinal stenosis. Surgery-related (operation time, complications, length of stay (LOS), American Society of Anesthesiologists physical status (ASA) score, C-reactive protein (CRP), white blood cell count, side of approach (unilateral/bilateral), patient-related outcome measures (PROMs) (Oswestry disability index (ODI), numeric rating scale of pain (NRS; leg-, back pain), EuroQol questionnaire (eQ-5D), core outcome measures index (COMI)), and radiological (dural sack cross-sectional area, Schizas score (SC), left and right lateral recess heights, and facet angles, respectively) parameters were extracted at different time points up to 1-year follow-up. The relationship of PROMs was analyzed using Spearman's rank correlation. Surgery-related outcome parameters were correlated with patient-centered and radiological outcomes utilizing a regression model to determine predictors for propensity score matching.
Complication (most often residual sensorimotor deficits and restenosis due to hematoma) rates were higher in the FED (33.3%) than MSD (13.5%) group (p < 0.05), while all complications in the FED group were observed within the first 20 FED patients. Operation time was higher in the FED, whereas LOS was higher in the MSD group. Age, SC, CRP revealed significant associations with PROMs. We did not observe significant differences in the endoscopic vs. microsurgical group in PROMs. The correlation between ODI and COMI was significantly high, and both were inversely correlated with eQ-5D, whereas the correlations of these PROMs with NRS findings were less pronounced.
Endoscopic treatment of lumbar spinal stenosis was similarly successful as the conventional microsurgical approach. Although FED was associated with higher complication rates in our single-center study experience, the distribution of complications indicated surgical learning curves to be the main factor of these findings. Future long-term prospective studies considering the surgical learning curve are warranted for reliable comparisons of these techniques.
与显微镜手术入路相比,内镜脊柱手术是一种全球范围内不断扩展的技术,被认为对治疗椎管狭窄更具微创性。然而,关于腰椎管狭窄症患者行经皮全内镜减压(FED)与传统显微镜减压(MSD)的疗效的证据仍然很少。我们进行了病例匹配比较,考虑了临床、实验室和影像学预测因素来评估治疗成功率。
我们纳入了 88 例连续就诊的腰椎中央型椎管狭窄患者(FED 组:36/88,40.9%;MSD 组:52/88,59.1%)。手术相关参数(手术时间、并发症、住院时间(LOS)、美国麻醉医师协会身体状况评分(ASA)、C 反应蛋白(CRP)、白细胞计数、手术入路侧别(单侧/双侧)、患者相关结局测量(PROMs)(Oswestry 残疾指数(ODI)、疼痛数字评分量表(NRS;下肢痛、腰痛)、EuroQol 问卷(eQ-5D)、核心结局测量指标(COMI))和影像学参数(硬脊膜囊横截面积、Schizas 评分(SC)、左侧和右侧侧隐窝高度、关节突角)在术后 1 年的不同时间点进行提取。使用 Spearman 秩相关分析 PROMs 之间的关系。使用回归模型将手术相关结局参数与以患者为中心的结局和影像学结局相关联,以确定倾向评分匹配的预测因素。
FED 组(33.3%)并发症(最常见的是由于血肿导致的感觉运动残留缺陷和再狭窄)发生率高于 MSD 组(13.5%)(p<0.05),而 FED 组的所有并发症均发生在最初的 20 例 FED 患者中。FED 组的手术时间较长,而 MSD 组的 LOS 较长。年龄、SC、CRP 与 PROMs 显著相关。我们在 FED 组和 MSD 组之间未观察到 PROMs 的显著差异。ODI 与 COMI 之间的相关性显著较高,并且都与 eQ-5D 呈负相关,而这些 PROMs 与 NRS 结果的相关性则不太明显。
在我们的单中心研究经验中,内镜治疗腰椎管狭窄症与传统显微镜手术入路同样有效。尽管 FED 组在我们的单中心研究经验中并发症发生率较高,但并发症的分布表明手术学习曲线是这些发现的主要因素。未来需要进行长期前瞻性研究,以比较这些技术。