Gordon D J, Trost D C, Hyde J, Whaley F S, Hannan P J, Jacobs D R, Ekelund L G
Lipid Metabolism-Atherogenesis Branch, NHLBI, Bethesda, MD 20892.
Circulation. 1987 Dec;76(6):1224-31. doi: 10.1161/01.cir.76.6.1224.
Seasonal variation of plasma cholesterol levels was studied in 1446 hypercholesterolemic 35- to 59-year-old male participants in the Lipid Research Clinics Coronary Primary Prevention Trial placebo group. Each man's serial cholesterol data, obtained at bimonthly intervals for 2.0 to 6.5 years, were analyzed as a separate periodic time series, and distributions of cycle zeniths and amplitudes were calculated. A highly significant (chi 2= 706, 2 degrees of freedom) seasonal effect, 7.4 mg/dl higher on December 30 than on June 30, was found. This effect was similar among the 12 LRC centers, including such disparate climates as those of Minneapolis and San Diego, and tended to be larger in the southern centers. Its magnitude was independent of baseline levels of plasma cholesterol and other baseline characteristics. Observed seasonal differences in weight and diet explained less than one-third of the seasonal variation in plasma cholesterol levels. Plasma low- and high-density lipoprotein cholesterol levels, analyzed similarly, also showed significant synchronous seasonal cycles. Plasma triglyceride levels showed a weaker irregular seasonal pattern, highest in midsummer and late autumn and lowest in spring. The etiologies and mechanisms for these seasonal patterns remain largely unknown.
在脂质研究临床冠心病一级预防试验安慰剂组中，对1446名年龄在35至59岁的高胆固醇血症男性参与者的血浆胆固醇水平的季节性变化进行了研究。每一名男性参与者每两个月一次、持续2.0至6.5年的系列胆固醇数据，被作为单独的周期性时间序列进行分析，并计算出周期顶点和振幅的分布情况。研究发现了一个高度显著的（卡方值=706，自由度为2）季节性效应，即12月30日的血浆胆固醇水平比6月30日高7.4毫克/分升。在12个脂质研究临床中心中，这种效应是相似的，包括明尼阿波利斯和圣地亚哥等气候差异很大的地方，并且在南方的中心往往更大。其幅度与血浆胆固醇的基线水平和其他基线特征无关。观察到的体重和饮食的季节性差异对血浆胆固醇水平季节性变化的解释不足三分之一。同样进行分析的血浆低密度和高密度脂蛋白胆固醇水平，也显示出显著的同步季节性周期。血浆甘油三酯水平呈现出较弱的不规则季节性模式，在仲夏和晚秋最高，在春季最低。这些季节性模式的病因和机制在很大程度上仍然未知。
