Speech Language Pathologist & Audiologist, Malaysia.
Department of Speech, Language and Hearing Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to Be University), Chennai, India, 600 116.
Int J Pediatr Otorhinolaryngol. 2020 Nov;138:110393. doi: 10.1016/j.ijporl.2020.110393. Epub 2020 Sep 19.
Distortion product otoacoustic emissions (DPOAE) in infants with Iron Deficiency Anemia (IDA) helps in understanding the cochlear status especially the functioning of outer hair cells.
To analyze the presence of DPOAE across frequencies and DP amplitude in infants with and without IDA.
DPOAE were recorded on 40 infants with IDA and 40 infants without IDA in the age range of 6-24 months. Cubic DPOAEs (2f1-f2) were measured at six f2 frequencies (1500 Hz, 2000 Hz, 3000 Hz, 4500 Hz, 6000 Hz & 8000 Hz) with primary tone stimulus of intensity L1 equal to 65 dBSPL and L2 equal to 55 dBSPL. Immittance audiometry was performed using 226 Hz probe tone prior to DPOAE recording to ascertain normal middle ear functioning.
DPOAEs were present in all infants with and without IDA across frequencies tested. DP amplitude across the frequencies did not show any statistically significant difference (p < 0.05) between anemic and non-anemic groups. There was no statistically significant difference observed when both the groups were compared in terms of gender and age.
The study indicated that reduced iron levels does not have any influence on outer hair cell functioning as there were no changes observed in the DPOAE amplitude levels between infants with IDA and infants without IDA. Iron status does not seem to have a direct effect on outer hair cell functioning in infants. However, fine structure DPOAEs can reveal even more precise changes (if any) that are caused due to iron deficiency.
患有缺铁性贫血（IDA）的婴儿的畸变产物耳声发射（DPOAE）有助于了解耳蜗状况，尤其是外毛细胞的功能。
分析患有和不患有 IDA 的婴儿在各频率下的 DPOAE 存在情况及 DP 振幅。
对 40 名患有 IDA 的婴儿和 40 名无 IDA 的婴儿（年龄在 6-24 个月之间）进行了 DPOAE 记录。在 6 个 f2 频率（1500 Hz、2000 Hz、3000 Hz、4500 Hz、6000 Hz 和 8000 Hz）上测量了立方 DPOAE（2f1-f2），初级音刺激强度 L1 为 65 dBSPL，L2 为 55 dBSPL。在进行 DPOAE 记录之前，使用 226 Hz 探测音进行声导抗测试，以确定中耳功能正常。
患有和不患有 IDA 的所有婴儿在测试的各频率上均存在 DPOAE。各频率的 DP 振幅在贫血组和非贫血组之间无统计学显著差异（p < 0.05）。在性别和年龄方面，两组之间也没有观察到统计学显著差异。
该研究表明，铁含量降低对外毛细胞功能没有影响，因为在患有 IDA 的婴儿和不患有 IDA 的婴儿之间，DPOAE 振幅水平没有观察到变化。铁状况似乎对外毛细胞功能没有直接影响。然而，精细结构 DPOAE 可以揭示更精确的变化（如果有），这些变化是由缺铁引起的。
