Ramachandra Deepashree Somanahalli, Uppunda Ajith Kumar, Suryanarayana Kumar Gavali
Vivekananda Memorial Hospital, A Unit of Swami Vivekananda Youth Movement (SVYM), Hanchipura Road, Saragur, Saragur Taluk, Mysuru District, Karnataka, 571121, India.
All India Institute of Speech and Hearing (AIISH), Manasagangothri, Mysuru, Karnataka, 570006, India.
J Otol. 2023 Jul;18(3):132-138. doi: 10.1016/j.joto.2023.05.005. Epub 2023 May 27.
Studies on animals have demonstrated that maternal iron deficiency anaemia (IDA) could result in decreased cochlear sensory hair cells and reduced amplitudes of distortion-product otoacoustic emissions (DPOAEs) of young guinea pigs. Thus, it is essential to study the functioning of cochlear hair cells using DPOAEs in human newborn babies with maternal IDA. The current study explores maternal IDA's effect on DPOAEs in newborn babies.
A total of 110 newborn babies with gestational age ≥34 weeks were considered and a 'between-subjects' design was used. The participants were divided into 3 groups- "Normal" (61 babies without maternal IDA), "Mild" (28 babies with mild maternal IDA) and "Moderate" (21 babies with moderate maternal IDA). The cord blood was collected and the DPOAEs were recorded for each baby for a range of frequencies (1 k - 8 kHz) and a range of intensities (70-40 dB SPL in 10 dB steps).
The analysis of both DP-gram and DP input-output (I/O) function showed that there was no significant difference (p > 0.05) across the normal, mild, and moderate groups in the overall presence of DPOAEs as well as the amplitude across frequencies or intensities (70-40 dB SPL). Also, the overall correlation of RBC indices with DPOAE amplitude across frequencies as well as the slope of the I/O function showed no relationship.
The current study concludes that there is no effect of late-term maternal IDA on the DPOAEs of newborn babies.
动物研究表明，母体缺铁性贫血（IDA）可导致幼年豚鼠耳蜗感觉毛细胞减少以及畸变产物耳声发射（DPOAE）幅度降低。因此，有必要利用DPOAE研究患有母体IDA的人类新生儿耳蜗毛细胞的功能。本研究探讨母体IDA对新生儿DPOAE的影响。
共纳入110名孕周≥34周的新生儿，并采用“组间”设计。参与者被分为3组——“正常组”（61名无母体IDA的婴儿）、“轻度组”（28名患有轻度母体IDA的婴儿）和“中度组”（21名患有中度母体IDA的婴儿）。采集脐带血，记录每个婴儿在一系列频率（1k - 8kHz）和一系列强度（70 - 40dB SPL，以10dB步长）下的DPOAE。
对DP图和DP输入-输出（I/O）功能的分析表明，在DPOAE的总体存在情况以及频率或强度（70 - 40dB SPL）范围内的幅度方面，正常组、轻度组和中度组之间无显著差异（p > 0.05）。此外，红细胞指数与频率范围内DPOAE幅度以及I/O功能斜率的总体相关性也无关联。
本研究得出结论，晚期母体IDA对新生儿的DPOAE没有影响。
