Struyker-Boudier H A, Janssen B J, Smits J F
Dept. of Pharmacology, University of Limburg, Maastricht, The Netherlands.
Clin Exp Hypertens A. 1987;9 Suppl 1:135-50. doi: 10.3109/10641968709160170.
The kidney plays a key role in the regulation of blood pressure. The sympathetic nervous system can influence many aspects of kidney function in relation to blood pressure control, e.g. renal vascular tone, intrarenal renin release and tubular reabsorption of electrolytes and fluid. The intrarenal distribution of adrenoceptors has now been studied on the basis of modern receptor ligand binding techniques combined with microscopic studies. The preferential localization of each adrenoceptor subtype within the kidney is reviewed. Furthermore, an attempt is made to describe the functional correlation of the presence of different adrenoceptor subtypes. Finally, the possible role of renal adrenoceptor abnormalities in the pathogenesis of hypertension is discussed.
肾脏在血压调节中起关键作用。交感神经系统可在血压控制方面影响肾脏功能的许多方面，例如肾血管张力、肾内肾素释放以及电解质和液体的肾小管重吸收。现已基于现代受体配体结合技术并结合显微镜研究对肾脏中肾上腺素能受体的分布进行了研究。本文综述了每种肾上腺素能受体亚型在肾脏内的优先定位。此外，还尝试描述不同肾上腺素能受体亚型存在的功能相关性。最后，讨论了肾脏肾上腺素能受体异常在高血压发病机制中的可能作用。
