Head W C, Berklacich F M, Malinin T I, Emerson R H
Southwestern Medical School, University of Texas Health Science Center, Dallas.
Clin Orthop Relat Res. 1987 Dec(225):22-36.
Patients with total hip arthroplasty (THA) and aseptic loosening associated with severe bone deficiency were treated with freeze-dried bone allografts of the proximal one-third of the femur. Twenty-two of the first 25 patients were available for review with an average follow-up period of 28 months. Significant functional improvement was obtained in 16 patients (73%). The following complications occurred with allograft revisions: dislocation, wound hematoma, joint instability, nonunion, implant failure, and acetabular loosening. Nine patients required additional surgical procedures. There have been no infections or rapid lysis indicative of an allograft rejection phenomenon. The 73% success at the two-year postoperative interval of incorporation of freeze-dried allografts for salvage situations has been encouraging. However, the long-term durability of these grafts is not known and will require further follow-up study.
接受全髋关节置换术（THA）且因严重骨缺损出现无菌性松动的患者，采用股骨近端三分之一的冻干同种异体骨进行治疗。前25例患者中有22例可供复查，平均随访期为28个月。16例患者（73%）获得了显著的功能改善。同种异体骨翻修出现了以下并发症：脱位、伤口血肿、关节不稳定、骨不连、植入物失败和髋臼松动。9例患者需要额外的手术。未发生感染或提示同种异体骨排斥现象的快速溶解。在挽救情况下，冻干同种异体骨植入术后两年的成功率为73%，这一结果令人鼓舞。然而，这些移植物的长期耐久性尚不清楚，需要进一步的随访研究。
