原发性高血压中胰岛素介导的红细胞镁蓄积受损。
Impaired insulin-mediated erythrocyte magnesium accumulation in essential hypertension.
作者信息
Paolisso G, Passariello N, Sgambato S, Torecca R, Buoninconti R, Varricchio M, D'Onofrio F
机构信息
Istituto di Medicina Generale, Terapia e Malattie del Metabolismo, 1st Medical School, University of Naples, Italy.
出版信息
Clin Sci (Lond). 1987 Nov;73(5):535-9. doi: 10.1042/cs0730535.
PMID:3315399
Abstract
- This study was designed to investigate variations in erythrocyte magnesium in the presence of insulin (0.1 unit/l) in hypertensive subjects. 2. Plasma and erythrocyte magnesium levels were found to be significantly lower in hypertensive than in normotensive subjects. 3. The impaired response to insulin (0.1 units/l) of erythrocytes from hypertensive patients was not reversed by elevated extracellular Mg2+ (3.6 mmol/l). 4. Erythrocytes of hypertensive subjects showed an increased membrane microviscosity compared with normotensive subjects. 5. Lidocaine decreased erythrocyte membrane microviscosity and increased erythrocyte magnesium levels in the presence of insulin.
摘要
- 本研究旨在调查高血压患者在存在胰岛素（0.1单位/升）的情况下红细胞镁的变化情况。2. 发现高血压患者的血浆和红细胞镁水平显著低于血压正常的受试者。3. 高血压患者红细胞对胰岛素（0.1单位/升）的反应受损，并不会因细胞外镁离子浓度升高（3.6毫摩尔/升）而得到改善。4. 与血压正常的受试者相比，高血压患者的红细胞表现出膜微粘度增加。5. 在存在胰岛素的情况下，利多卡因可降低红细胞膜微粘度并提高红细胞镁水平。
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