Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.
Department of Pathology, University College Hospital; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Niger Postgrad Med J. 2020 Oct-Dec;27(4):331-335. doi: 10.4103/npmj.npmj_231_20.
Hydatidiform mole (HM) is the most common gestational trophoblastic disease. P57 has been reported to be helpful in differentiating between partial and complete HMs.
The study aims to evaluate the P57 immunohistochemical (IHC) marker as a useful ancillary investigation to differentiate complete hydatidiform mole (CHM) from partial hydatidiform mole (PHM).
A retrospective study of all histologically diagnosed HM cases over a 20 year period was undertaken. Clinicopathological parameters were extracted from the surgical day book and medical record archives. Archival haematoxylin- and eosin-stained slides and formalin-fixed paraffin-embedded tissue blocks of all cases of HM diagnosed within the study period were retrieved and reviewed. Cases of HM were reclassified using the P57 IHC marker. The data obtained were analysed using the SPSS version 23.
One hundred cases of HMs were studied. CHM accounted for 68%, while PHM accounted for the remaining 32%. The incidence of HM was 2.98 cases per 1000 deliveries. The ratio of CHM to PHM was found to be 2.1:1. Seventy-two per cent of the cases were diagnosed in the first trimester, while the remaining 28% were diagnosed in the second trimester of pregnancy. Based on the P57 IHC staining pattern, HM cases were finally reclassified into 68 cases of CHM and 32 cases of PHM. The age range for all the HM cases was 18-50 years with the majority of the cases seen in the third and fourth decades of life.
P57 could be useful as an ancillary investigation in confirming the diagnosis of CHM and differentiating it from PHM, particularly in difficult and challenging cases.
葡萄胎（HM）是最常见的妊娠滋养细胞疾病。已有报道称 P57 有助于区分部分性和完全性 HM。
本研究旨在评估 P57 免疫组织化学（IHC）标志物作为辅助诊断完全性葡萄胎（CHM）与部分性葡萄胎（PHM）的有用方法。
对 20 年来所有经组织学诊断的 HM 病例进行回顾性研究。从手术日簿和病历档案中提取临床病理参数。检索并回顾研究期间所有 HM 病例的苏木精-伊红染色切片和福尔马林固定石蜡包埋组织块。使用 P57 IHC 标志物对 HM 病例进行重新分类。使用 SPSS 版本 23 分析获得的数据。
研究了 100 例 HM。CHM 占 68%，PHM 占 32%。HM 的发病率为每 1000 例分娩 2.98 例。CHM 与 PHM 的比例为 2.1:1。72%的病例在孕早期诊断，其余 28%在孕中期诊断。根据 P57 IHC 染色模式，HM 病例最终重新分类为 68 例 CHM 和 32 例 PHM。所有 HM 病例的年龄范围为 18-50 岁，大多数病例见于 30-40 岁。
P57 可作为辅助诊断 CHM 的方法，有助于区分 CHM 和 PHM，特别是在疑难和挑战性病例中。
