Mayer O, Polívková H
Department of Clinical Pharmacology, Faculty of Medicine, Plzen, Czechoslovakia.
Cor Vasa. 1987;29(4 Suppl 1):37-41.
The paper offers therapeutic experience with guanfacine (Estulic Sandoz) in large and small doses in patients with hypertension. A daily dose of 3-4 mg of guanfacine led to a decrease in blood pressure in about half of patients with moderate to severe hypertension. However, therapy had to be discontinued in several instances due to frequent occurrence of adverse side effects. The recently recommended smaller doses (2 x 1 mg) of guanfacine indicated primarily in patients with renal dysfunction or diabetes mellitus resulted in an extremely good therapeutic response; the frequency of undesirable effects was about the same as with other antihypertensive therapeutic protocols. The drug seems to offer more benefits in special indications with a concomitant disease rather than as a third drug of a combination used in severe hypertension.
该论文提供了使用胍法辛（桑多斯公司的埃斯图利克）大剂量和小剂量治疗高血压患者的经验。每日3 - 4毫克的胍法辛剂量可使约一半的中重度高血压患者血压下降。然而，由于不良反应频繁发生，在一些情况下不得不停止治疗。最近推荐的较小剂量（2×1毫克）胍法辛主要用于肾功能不全或糖尿病患者，显示出极佳的治疗反应；不良反应的发生率与其他抗高血压治疗方案大致相同。该药物似乎在伴有合并症的特殊适应症中比作为重度高血压联合用药中的第三种药物更有益。
